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المؤلفAbdulrahman, Nabeel
المؤلفIbrahim, Meram
المؤلفJoseph, Jensa Mariam
المؤلفElkoubatry, Hanan Mahmoud
المؤلفAl-Shamasi, Al Anood
المؤلفRayan, Menatallah
المؤلفGadeau, Alain Pierre
المؤلفAhmed, Rashid
المؤلفEldassouki, Hussein
المؤلفHasan, Anwarul
المؤلفMraiche, Fatima
تاريخ الإتاحة2023-03-27T10:03:43Z
تاريخ النشر2022-06-01
اسم المنشورMolecular and Cellular Biochemistry
المعرّفhttp://dx.doi.org/10.1007/s11010-022-04411-6
الاقتباسAbdulrahman, N., Ibrahim, M., Joseph, J.M. et al. Empagliflozin inhibits angiotensin II-induced hypertrophy in H9c2 cardiomyoblasts through inhibition of NHE1 expression. Mol Cell Biochem 477, 1865–1872 (2022). https://doi.org/10.1007/s11010-022-04411-6
الرقم المعياري الدولي للكتاب03008177
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85127244636&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/41349
الملخصDiabetes mellitus (DM)-induced cardiac morbidities have been the leading cause of death among diabetic patients. Recently, sodium-glucose cotransporter-2 (SGLT-2) inhibitors including empagliflozin (EMPA), which have been approved for the treatment of DM, have gained attention for their cardioprotective effect. The mechanism by which SGLT-2 inhibitors exert their cardioprotective effect remains unclear. Recent studies have suggested that EMPA exerts its cardioprotective effect by inhibiting the Na+/H+ exchanger (NHE), a group of membrane proteins that regulate intracellular pH and cell volume. Increased activity and expression of NHE isoform 1 (NHE1), the predominant isoform expressed in the heart, leads to cardiac hypertrophy. p90 ribosomal s6 kinase (p90 RSK) has been demonstrated to stimulate NHE1 activity. In our study, H9c2 cardiomyoblasts were treated with angiotensin II (ANG) to activate NHE1 and generate a hypertrophic model. We aimed to understand whether EMPA reverses the ANG-induced hypertrophic response and to elucidate the molecular pathway contributing to the cardioprotective effect of EMPA. Our study demonstrated that ANG-induced hypertrophy of H9c2 cardiomyoblasts is accompanied with increased SGLT-1 and NHE1 protein expression, an effect which is prevented in the presence of EMPA. EMPA reduces ANG-induced hypertrophy through the inhibition of SGLT-1 and NHE1 expression.
راعي المشروعOpen Access funding provided by the Qatar National Library. This publication was supported by Qatar University Student Grant No. QUST-2-CPH-2019-9. “The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.”
اللغةen
الناشرSpringer
الموضوعAngiotensin II
Cardiomyocyte hypertrophy
Empagliflozin
H9c2 cardiomyoblasts
NHE1
SGLT-1/2
العنوانEmpagliflozin inhibits angiotensin II-induced hypertrophy in H9c2 cardiomyoblasts through inhibition of NHE1 expression
النوعArticle
الصفحات1865-1872
رقم العدد6
رقم المجلد477
ESSN1573-4919
dc.accessType Open Access


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