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Medicine Research [472 items ]
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Characterising Alzheimer's disease through integrative NMR- and LC-MS-based metabolomics
( Elsevier , 2021 , Article)BackgroundAlzheimer's Disease (AD) is a complex and multifactorial disease and novel approaches are needed to illuminate the underlying pathology. Metabolites comprise the end-product of genes, transcripts, and protein ... -
Shotgun-based proteomics of extracellular vesicles in Alzheimer’s disease reveals biomarkers involved in immunological and coagulation pathways
( Nature Research , 2021 , Article)Alzheimer’s disease (AD) is the most common form of dementia and without readily available clinical biomarkers. Blood-derived proteins are routinely used for diagnostics; however, comprehensive plasma profiling is challenging ... -
Identifying metabolic alterations in newly diagnosed small cell lung cancer patients
( Elsevier , 2021 , Article)BackgroundSmall cell lung cancer (SCLC) is a malignant disease with poor prognosis. At the time of diagnosis most patients are already in a metastatic stage. Current diagnosis is based on imaging, histopathology, and ... -
Calmodulin Interacts and Regulates Enzyme Activity of the Mammalian Sperm Phospholipase C
( Elsevier , 2017 , Article)Sperm-specific Phospholipase C zeta (PLCζ) is widely considered to be the sole, physiological stimulus responsible for the generation of Ca2+ oscillations that induce egg activation and early embryo development during ... -
The Arrhythmogenic E105A CAM Mutation Dysregulates Normal Cardiac Function in Zebrafish by Altering CAM-Ca2+ and CAM-RyR2 Interactions
( Elsevier , 2019 , Article)Calmodulin (CaM) is a multifunctional calcium (Ca2+)-binding messenger that directly interacts with the cardiac ryanodine receptor 2 (RyR2), a large transmembrane Ca2+ channel that mediates Ca2+ release from the sarcoplasmic ... -
Defective Interaction of Cam with RyR2 Cam-Binding Pocket Might Contribute to Arrhythmogenic Cardiac Disease
( Elsevier , 2020 , Article)Ryanodine receptor 2 (RyR2) is a large transmembrane calcium (Ca2+) release channel that mediates Ca2 release from the sarcoplasmic reticulum to activate cardiac muscle contraction. Calmodulin (CaM) regulation of RyR2 is ... -
Calmodulin Mutations Associated with Congenital Cardiac Disease Display Novel Biophysical and Biochemical Characteristics
( Elsevier , 2018 , Article)Calmodulin (CaM) is a cytoplasmic multifunctional calcium (Ca2+)-binding messenger that interacts with the cardiac ryanodine receptor (RyR2), a large transmembrane Ca2+ channel that mediates Ca2+ release from the sarcoplasmic ... -
Presence of high-risk HPVs, EBV, and MMTV in human triple-negative breast cancer.
( Taylor and Francis , 2021 , Article)Breast cancer, the most frequent disease amongst women worldwide, accounts for the highest cancer-related mortality rate. Triple-negative breast cancer (TNBC) subtype encompasses ~15% of all breast cancers and lack estrogen, ... -
Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity
( Elsevier , 2019 , Article)The study of rare families with inherited pain insensitivity can identify new human-validated analgesic drug targets. Here, a 66-yr-old female presented with nil requirement for postoperative analgesia after a normally ... -
Appendiceal carcinoid in a pediatric patient with Peutz-Jeghers syndrome: A case report and comprehensive literature review.
( Lippincott, Williams & Wilkins , 2021 , Report)Peutz-Jeghers syndrome (PJS), a rare autosomal dominant disorder, is characterized by mucocutaneous pigmentations, hamartomatous polyps in the gastrointestinal tract, and a high risk of developing various malignancies. To ... -
Periprocedural Anticoagulation Management of Patients receiving Warfarin in Qatar: A Prospective Cohort Study
( Elsevier , 2021 , Article)Background: The use of anticoagulant bridging remains controversial. This study was conducted to evaluate our warfarin periprocedural management in Qatar and investigate the associated clinical outcomes with such management. ... -
Quality of life, sleep quality, depression, anxiety, stress, eating habits, and social bounds in nurses during the coronavirus disease 2019 pandemic in qatar (The PROTECTOR study): A cross-sectional, comparative study
( MDPI , 2021 , Article)There have been numerous concerns regarding the physical and mental health of nurses during the COVID-19 pandemic. Stress, sleep deprivation, anxiety, and depression potentiated nurses’ vulnerability to poor eating habits. ... -
Peer-assisted Learning Associated with Team-based Learning in Dental Education
( Health Professions Education , 2017 , Article)Peer-assisted learning is one of many educational strategies that can assist students׳ learning and their professional development. Its value could be enhanced if combined with a student centered learning strategy such as ... -
Expression and subcellular localization of Discoidin Domain Receptor 1 (DDR1) define prostate cancer aggressiveness
( BMC , 2021 , Article)Background: The Discoidin Domain Receptor 1 (DDR1) is one of the two members of a unique family of receptor tyrosine kinase receptors that signal in response to collagen, which has been implicated in cancer progression. ... -
Empirical Comparisons of 12 Meta-analysis Methods for Synthesizing Proportions of Binary Outcomes
( Springer , 2021 , Article)Background: Meta-analysis is increasingly used to synthesize proportions (e.g., disease prevalence). It can be implemented with widely used two-step methods or one-step methods, such as generalized linear mixed models ... -
Rapid evidence synthesis approach for limits on the search date: how rapid could it be?
( John Wiley and Sons , 2021 , Article)Rapid reviews have been widely employed to support timely decision-making, and limiting the search date is the most popular approach in published rapid reviews. We assessed the accuracy and workload of search date limits ... -
A Golgi study of neurons in the camel cerebellum (Camelus dromedarius)
( Wiley , 2021 , Article)Neurons in the cerebellar cortex of camels were studied using modified Golgi impregnation methods. Neurons were classified according to their position, morphology of their soma, density and distribution of dendrites, and ... -
Unifying the diagnosis of gestational diabetes mellitus: Introducing the NPRP criteria
( Elsevier , 2021 , Article)AimsDisagreement about the appropriate criteria for the diagnosis of gestational diabetes mellitus (GDM) persists. This study examines an alternative approach which combines information from all time-points on the glucose ... -
Evaluation of Gender Inequity in Thyroid Cancer Diagnosis: Differences by Sex in US Thyroid Cancer Incidence Compared with a Meta-analysis of Subclinical Thyroid Cancer Rates at Autopsy
(2021 , Article)Importance: Thyroid cancer is more common in women than in men, but the associated causes of these differences are not fully understood. Objective: To compare sex-specific thyroid cancer rates in the US to the prevalence ... -
The odds ratio is “portable” but not the relative risk: Time to do away with the log link in binomial regression
( Elsevier , 2021 , Article)Objectives: In a recent paper we suggest that the relative risk (RR) be replaced with the odds ratio (OR) as the effect measure of choice in clinical epidemiology. In response, Chu, and colleagues raise several points that ...
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