Browsing College of Medicine by Author "Eid, Ali H."
Now showing items 1-20 of 65
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2-Nucleobase-substituted 4,6-Diaminotriazine Analogs: Synthesis and Anti-cancer Activity in 5-Fluorouracil-Sensitive and Resistant Colorectal Cancer Cells.
Hamze, Khalil; Abdallah, Rola H; Younis, Nour K; Fardoun, Manal; Darwiche, Nadine; Kobeissy, Firas; Iratni, Rabah; Bouhadir, Kamal; Eid, Ali H... more authors ... less authors ( Bentham Science Publishers , 2022 , Article)Cancer continues to be the second leading cause of death worldwide with colorectal cancer (CRC) being the third most common type. Despite significant advances in cancer therapies, current treatment of CRC remains suboptimal. ... -
Adipose tissue immunomodulation: A novel therapeutic approach in cardiovascular and metabolic diseases
Alzaim, Ibrahim; Hammoud, Safaa H.; Al-Koussa, Houssam; Ghazi, Alaa; Eid, Ali H.; El-Yazbi, Ahmed F.... more authors ... less authors ( Frontiers Media , 2020 , Article)Adipose tissue is a critical regulator of systemic metabolism and bodily homeostasis as it secretes a myriad of adipokines, including inflammatory and anti-inflammatory cytokines. As the main storage pool of lipids, ... -
Adipose tissue mitochondrial dysfunction and cardiometabolic diseases: On the search for novel molecular targets
Ibrahim, AlZaim; Eid, Ali H.; Abd-Elrahman, Khaled S.; El-Yazbi, Ahmed F. ( Elsevier , 2022 , Article)Cardiometabolic diseases present an escalating global health and economic burden. Such a surge is driven by epidemic prevalence rates of metabolic disorders, such as obesity and type 2 diabetes, and their associated ... -
Antibody-dependent enhancement (ADE) of SARS-CoV-2 in patients exposed to MERS-CoV and SARS-CoV-2 antigens
Thomas, Swapna; Smatti, Maria K.; Alsulaiti, Haya; Zedan, Hadeel T.; Eid, Ali H.; Hssain, Ali A.; Abu Raddad, Laith J.; Gentilcore, Giusy; Ouhtit, Allal; Althani, Asmaa A.; Nasrallah, Gheyath K.; Grivel, Jean Charles; Yassine, Hadi M.... more authors ... less authors ( Wiley , 2024 , Article)This study evaluated the potential for antibody-dependent enhancement (ADE) in serum samples from patients exposed to Middle East respiratory syndrome coronavirus (MERS-CoV). Furthermore, we evaluated the effect of severe ... -
Bariatric Surgery Improves Serum CD40L Levels as a Predictor of Cardiovascular Risk: Systematic Review and Meta-analysis
Jamialahamdi, Tannaz; Eid, Ali H.; Nguyen, Ninh T.; Gadde, Kishore M.; Sukhorukov, Vasily N.; Almahmeed, Wael; Kroh, Matthew; Sahebkar, Amirhossein... more authors ... less authors (2024 , Article)CD40 and its ligand have been recently implicated in the pathogenesis of cardiovascular disease (CVD). This meta-analysis examined the effect of bariatric surgery in reducing circulating CD40L levels. A systematic review ... -
Beta-caryophyllene exhibits anti-proliferative effects through apoptosis induction and cell cycle modulation in multiple myeloma cells
Mannino, Federica; Pallio, Giovanni; Corsaro, Roberta; Minutoli, Letteria; Altavilla, Domenica; Vermiglio, Giovanna; Allegra, Alessandro; Eid, Ali H.; Bitto, Alessandra; Squadrito, Francesco; Irrera, Natasha... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Cannabinoid receptors, which are widely distributed in the body, have been considered as possible pharmacological targets for the management of several tumors. Cannabinoid type 2 receptors (CB2Rs) belong to the G protein-coupled ... -
Biochemical and cellular basis of oxidative stress: Implications for disease onset
Aramouni, Karl; Assaf, Roland; Shaito, Abdullah; Fardoun, Manal; Al-Asmakh, Maha; Sahebkar, Amirhossein; Eid, Ali H.... more authors ... less authors ( Wiley , 2023 , Article Review)Cellular oxidation–reduction (redox) systems, which encompass pro- and antioxidant molecules, are integral components of a plethora of essential cellular processes. Any dysregulation of these systems can cause molecular ... -
Bridging conventional medicine and traditional, complementary, and alternative approaches: Fostering collaborative attempts for a holistic healthcare system
Eid, Ali H.; Sahebkar, Amirhossein ( Elsevier , 2023 , Other)Dear Editor, We read the paper entitled “The future of integrative health: vision, values, and principles for positive, sustainable systemic change” by Kemper, which was published last month.1 The points discussed therein ... -
Burden and disease pathogenesis of influenza and other respiratory viruses in diabetic patients
Swapna, Thomas; Ouhtit, Allal; Al Khatib, Hebah A.; Eid, Ali H.; Mathew, Shilu; Nasrallah, Gheyath K.; Emara, Mohamed M.; Al Maslamani, Muna A.; Yassine, Hadi M.... more authors ... less authors ( Elsevier , 2022 , Article Review)Over the past two decades, diabetes mellitus (DM) has been receiving increasing attention among autoimmune diseases. The prevalence of type 1 and type 2 diabetes has increased rapidly and has become one of the leading ... -
C-peptide in diabetes: A player in a dual hormone disorder?
Dakroub, Ali; Dbouk, Ali; Asfour, Aref; Nasser, Suzanne A.; El-Yazbi, Ahmed F.; Sahebkar, Amirhossein; Eid, Assaad A.; Iratni, Rabah; Eid, Ali H.... more authors ... less authors ( Wiley-Blackwell , 2024 , Article)C-peptide, a byproduct of insulin synthesis believed to be biologically inert, is emerging as a multifunctional molecule. C-peptide serves an anti-inflammatory and anti-atherogenic role in type 1 diabetes mellitus (T1DM) ... -
Cannabinoids and Myocardial Ischemia: Novel insights, Updated Mechanisms, and Implications for Myocardial Infarction
El Dahan, Karim Seif; Machtoub, Dima; Massoud, Gaelle; Nasser, Suzanne A.; Hamam, Bassam; Kobeissy, Firas; Zouein, Fouad A.; Eid, Ali H.... more authors ... less authors ( Bentham Science Publishers , 2022 , Article)Cannabis is the most widely trafficked and abused illicit drug due to its calming psychoactive properties. It has been increasingly recognized as having potential health benefits and relatively less adverse health effects ... -
Cardioprotective Effect of Rheum turkestanicum Against Doxorubicin-Induced Toxicity in Rats
Hosseini, Azar; Safari, Mohammad Kazem; Rajabian, Arezoo; Boroumand-Noughabi, Samaneh; Eid, Ali H.; Al Dhaheri, Yusra; Gumpricht, Eric; Sahebkar, Amirhossein... more authors ... less authors ( Frontiers Media S.A. , 2022 , Article)Background: Doxorubicin as an anti-cancer drug causes cardiotoxicity, limiting its tolerability and use. The mechanism of toxicity is due to free radical production and cardiomyocytes injury. This research evaluated Rheum ... -
Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats
Hosseini, Azar; Ghorbani, Atieh; Alavi, Mohaddeseh Sadat; Forouhi, Nima; Rajabian, Arezoo; Boroumand-Noughabi, Samaneh; Sahebkar, Amirhossein; Eid, Ali H.... more authors ... less authors ( Frontiers Media SA , 2023 , Article)Introduction: Oxidative stress is a major instigator of various cardiovascular diseases, including myocardial infarction (MI). Despite available drugs, there is still an increased need to look for alternative therapies or ... -
Carnosol Is a Novel Inhibitor of p300 Acetyltransferase in Breast Cancer
Alsamri, Halima; Hasasna, Hussain El; Baby, Bincy; Alneyadi, Aysha; Dhaheri, Yusra Al; Ayoub, Mohammed Akli; Eid, Ali H.; Vijayan, Ranjit; Iratni, Rabah... more authors ... less authors ( Frontiers Media S.A. , 2021 , Article)Carnosol, a natural polyphenol abundant in edible plants such as sage, rosemary, and oregano, has shown promising anticancer activity against various types of cancers. Nonetheless, very little is known about its molecular ... -
Chemical Analysis and Investigation of Biological Effects of Salvia officinalis Essential Oils at Three Phenological Stages
Assaggaf, Hamza M.; Naceiri Mrabti, Hanae; Rajab, Bodour S.; Attar, Ammar A.; Alyamani, Reema A.; Hamed, Munerah; El Omari, Nasreddine; El Menyiy, Naoual; Hazzoumi, Zakaria; Benali, Taoufiq; Al-Mijalli, Samiah Hamad; Zengin, Gokhan; AlDhaheri, Yusra; Eid, Ali H.; Bouyahya, Abdelhakim... more authors ... less authors ( MDPI , 2022 , Article)Salvia officinalis is a medicinal plant used to treat some diseases, including microbial infections and diabetes. Different studies showed the biological and pharmacological properties of this species. The aim of this study ... -
Combination of Angiotensin (1-7) Agonists and Convalescent Plasma as a New Strategy to Overcome Angiotensin Converting Enzyme 2 (ACE2) Inhibition for the Treatment of COVID-19
Issa, Hawraa; Eid, Ali H.; Berry, Bassam; Takhviji, Vahideh; Khosravi, Abbas; Mantash, Sarah; Nehme, Rawan; Hallal, Rawan; Karaki, Hussein; Dhayni, Kawthar; Faour, Wissam H.; Kobeissy, Firas; Nehme, Ali; Zibara, Kazem... more authors ... less authors ( Frontiers , 2021 , Article)Coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently the most concerning health problem worldwide. SARS-CoV-2 infects cells by binding to ... -
A comparative study on chemical profiles and biological activities of different extracts of three Verbascum species from Turkey: In vitro, in silico and network pharmacological approaches
Zengin, Gokhan; Yagi, Sakina; Kopjar, Mirela; Ćorković, Ina; Uba, Abdullahi Ibrahim; Yildiztugay, Evren; Kumar, Sathish; Rengasamy, Kannan RR; AlDhaheri, Yusra; Eid, Ali H.... more authors ... less authors ( Elsevier , 2023 , Article)The present study aimed to evaluate the antioxidant and enzyme inhibition properties of aerial part of Verbascum cheiranthifolium Boiss. V. myriocarpum Boiss. & Heldr. and V. pyroliforme (Boiss. & Heldr.) Kuntze as well ... -
Corrigendum to “Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs” [Biochem. Pharmacol. 186 (2021) 114491]
Hammoud, Safaa H.; AlZaim, Ibrahim; Mougharbil, Nahed; Koubar, Sahar; Eid, Ali H.; Eid, Assaad A.; El-Yazbi, Ahmed F.... more authors ... less authors ( Elsevier , 2023 , Other)We regret to report that a mistake occurred in preparation of Fig. 4. The modified figure is included below. We apologize for any confusion this might have created. -
Could antigen presenting cells represent a protective element during sars-cov-2 infection in children?
Lauro, Rita; Irrera, Natasha; Eid, Ali H.; Bitto, Alessandra ( MDPI , 2021 , Article)Antigen Presenting Cells (APC) are immune cells that recognize, process, and present antigens to lymphocytes. APCs are among the earliest immune responders against an antigen. Thus, in patients with COVID-19, a disease ... -
Covid-19 in pediatric patients: A focus on CHD patients
Zareef, Rana O.; Younis, Nour K.; Bitar, Fadi; Eid, Ali H.; Arabi, Mariam ( Frontiers Media S.A. , 2020 , Article)Coronavirus disease 2019 (COVID-19) is a global pandemic caused by SARS-CoV-2 virus. As of the 30th of September 2020, around 34,000,000 cases have been reported globally. Pediatrics with underlying congenital heart disease ...