Browsing College of Medicine by Author "Salem, Rola"
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The Arrhythmogenic E105A CAM Mutation Dysregulates Normal Cardiac Function in Zebrafish by Altering CAM-Ca2+ and CAM-RyR2 Interactions
Nomikos, Michail; I. Da’as, Sahar; Thanassoulas, Angelos; Salem, Rola; L. Calver, Brian; Saleh, Alaaeldin; Al-Maraghi, Ali; K. Nasrallah, Gheyath; Safieh-Garabedian, Bared; Toft, Egon; Nounesis, George; Lai, F. Anthony... more authors ... less authors ( Elsevier , 2019 , Article)Calmodulin (CaM) is a multifunctional calcium (Ca2+)-binding messenger that directly interacts with the cardiac ryanodine receptor 2 (RyR2), a large transmembrane Ca2+ channel that mediates Ca2+ release from the sarcoplasmic ... -
Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model
Da’as, Sahar Isa; Hasan, Waseem; Salem, Rola; Younes, Nadine; Abdelrahman, Doua; Mohamed, Iman A.; Aldaalis, Arwa; Temanni, Ramzi; Mathew, Lisa Sara; Lorenz, Stephan; Yacoub, Magdi; Nomikos, Michail; Nasrallah, Gheyath K.; Fakhro, Khalid A.... more authors ... less authors ( MDPI , 2022 , Article)Variants in cardiac myosin-binding protein C (cMyBP-C) are the leading cause of inherited hypertrophic cardiomyopathy (HCM), demonstrating the key role that cMyBP-C plays in the heart’s contractile machinery. To investigate ...