Browsing College of Medicine by Author "n 94093822"
Now showing items 1-14 of 14
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Acinic cell carcinoma of the breast: A comprehensive review
Azra, Ajkunic; Skenderi, Faruk; Shaker, Nada; Akhtar, Saghir; Lamovec, Janez; Gatalica, Zoran; Vranic, Semir... more authors ... less authors ( Elsevier , 2022 , Article)Acinic cell carcinoma of the breast is a rare special subtype of breast cancer in the category of salivary gland-type tumors. It is morphologically similar to acinic cell carcinomas of salivary glands and pancreas and has ... -
Ang-(1-7)/ MAS1 receptor axis inhibits allergic airway inflammation via blockade of Src-mediated EGFR transactivation in a murine model of asthma.
El-Hashim, Ahmed Z; Khajah, Maitham A; Babyson, Rhema S; Renno, Waleed M; Ezeamuzie, Charles I; Benter, Ibrahim F; Akhtar, Saghir... more authors ... less authors ( PLoS ONE , 2019 , Article)The angiotensin-(1-7) [Ang-(1-7)]/MAS1 receptor signaling axis is a key endogenous anti-inflammatory signaling pathway. However, the mechanisms by which its mediates the anti-inflammatory effects are not completely understood. ... -
Chronic administration of nano-sized PAMAM dendrimers in vivo inhibits EGFR-ERK1/2-ROCK signaling pathway and attenuates diabetes-induced vascular remodeling and dysfunction.
Akhtar, Saghir; Chandrasekhar, Bindu; Yousif, Mariam Hm; Renno, Waleed; Benter, Ibrahim F; El-Hashim, Ahmed Z... more authors ... less authors ( Elsevier , 2019 , Article)We investigated whether chronic administration of nano-sized polyamidoamine (PAMAM) dendrimers can have beneficial effects on diabetes-induced vascular dysfunction by inhibiting the epidermal growth factor receptor ... -
COVID-19 and Alzheimer's disease: Impact of lockdown and other restrictive measures during the COVID-19 pandemic.
Nawaz, Ahmed Daniyal; Haider, Mohammad Zulqurnain; Akhtar, Saghir ( the Association of Basic Medical Sciences , 2023 , Article Review)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection initially results in respiratory distress symptoms but can also lead to central nervous system (CNS) and neurological manifestations, significantly ... -
Critical appraisal of predatory journals in pathology.
AlAhmad, Yaman M; Abdelhafez, Ibrahim; Cyprian, Farhan S; Akhtar, Saghir; Skenderi, Faruk; Vranic, Semir... more authors ... less authors ( BMJ , 2019 , Article)Predatory journals refer to journals that recruit articles through aggressive marketing and spam emails, promising a quick, but not robust, review and fast open-access (OA) publication, thus compromising scholarly publishing ... -
Diabetes-induced peripheral neuropathy: Is prescribing physical exercise the answer?
Akhtar, Saghir ( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2024 , Other)Diabetes mellitus, a chronic metabolic disorder characterized by hyperglycemia, has become a global health concern with an increasing prevalence worldwide. The International Diabetes Federation (IDF) estimates that over ... -
Epstein-Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial-Mesenchymal Transition and Cancer Progression.
Cyprian, Farhan S; Al-Farsi, Halema F; Vranic, Semir; Akhtar, Saghir; Al Moustafa, Ala-Eddin ( Frontiers Media , 2018 , Article Review)Oncoviruses are implicated in around 20% of all human cancers including both solid and non-solid malignancies. Epstein-Barr virus (EBV) and human papillomaviruses (HPVs) are the most common oncoviruses worldwide. Currently, ... -
Epstein-Barr Virus in Gliomas: Cause, Association, or Artifact?
Akhtar, Saghir; Vranic, Semir; Cyprian, Farhan Sachal; Al Moustafa, Ala-Eddin ( Frontiers Media , 2018 , Article Review)Gliomas are the most common malignant brain tumors and account for around 60% of all primary central nervous system cancers. Glioblastoma multiforme (GBM) is a grade IV glioma associated with a poor outcome despite recent ... -
Is there truly an increase in risk of cardiovascular and hematological adverse events with vascular endothelial growth factor receptor tyrosine kinase inhibitors?
Furuya-Kanamori, Luis; Doi, Suhail Ar; Onitilo, Adedayo; Akhtar, Saghir ( Taylor & Francis , 2019 , Article)Recent studies have shown an increase risk of cardiovascular and hematological adverse events associated with vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs). The authors hypothesize that the ... -
Mitigating Cardiotoxicity of Dendrimers: Angiotensin-(1-7) via Its Mas Receptor Ameliorates PAMAM-Induced Cardiac Dysfunction in the Isolated Mammalian Heart
Akhtar, Saghir; Babiker, Fawzi; Akhtar, Usman A.; Benter, Ibrahim F. ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Aim: The influence of the physiochemical properties of dendrimer nanoparticles on cardiac contractility and hemodynamics are not known. Herein, we investigated (a) the effect of polyamidoamine (PAMAM) dendrimer generation ... -
The Role of Epstein-Barr Virus in Cervical Cancer: A Brief Update.
Vranic, Semir; Cyprian, Farhan Sachal; Akhtar, Saghir; Al Moustafa, Ala-Eddin ( Frontiers Media , 2018 , Article Review)Epstein-Barr virus (EBV) belongs to the group of gamma-herpes viruses and was the first recognized human oncovirus. EBV is responsible for infectious mononucleosis and multiple lymphoid and epithelial malignancies including ... -
Targeted immunotherapy with a checkpoint inhibitor in combination with chemotherapy: A new clinical paradigm in the treatment of triple-negative breast cancer.
Cyprian, Farhan S; Akhtar, Saghir; Gatalica, Zoran; Vranic, Semir ( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2019 , Article Review)The treatment of several solid and hematologic malignancies with immune checkpoint inhibitors (against PD-1/PD-L1) has dramatically changed the cancer treatment paradigm. However, no checkpoint inhibitors were previously ... -
An Updated Review of the Biomarkers of Response to Immune Checkpoint Inhibitors in Merkel Cell Carcinoma: Merkel Cell Carcinoma and Immunotherapy
Fojnica, Adnan; Ljuca, Kenana; Akhtar, Saghir; Gatalica, Zoran; Vranic, Semir ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Merkel cell carcinoma (MCC) is primarily a disease of the elderly Caucasian, with most cases occurring in individuals over 50. Immune checkpoint inhibitors (ICI) treatment has shown promising results in MCC patients. ... -
Vitamin D and Its Potential Interplay With Pain Signaling Pathways
Habib, Abdella M; Nagi, Karim; Thillaiappan, Nagendra Babu; Akhtar, Saghir; vijayakumar, sukumaran ( Frontiers Media , 2020 , Article Review)About 50 million of the U.S. adult population suffer from chronic pain. It is a complex disease in its own right for which currently available analgesics have been deemed woefully inadequate since ~20% of the sufferers ...