Browsing College of Medicine by Author "n 2011087789"
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Activation of K7 channels with the anticonvulsant retigabine alleviates neuropathic pain behaviour in the streptozotocin rat model of diabetic neuropathy.
Djouhri, Laiche; Malki, MohammedImad; Zeidan, Asad; Nagi, Karim; Smith, Trevor ( Taylor & Francis (Routledge) , 2019 , Article)Diabetic peripheral neuropathy (DPN) is the most incapacitating complication of diabetes mellitus. Up to 50% of patients with DPN develop peripheral neuropathic pain (PNP). The underlying ionic and molecular mechanisms of ... -
Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation
Mansour, Ahmed; Nagi, Karim; Dallaire, Paul; Lukasheva, Viktoriya; Le Gouill, Christian; Bouvier, Michel; Pineyro, Graciela... more authors ... less authors ( American Chemical Society , 2021 , Article)Prolonged exposure to opioid receptor agonists triggers adaptations in the adenylyl cyclase (AC) pathway that lead to enhanced production of cyclic adenosine monophosphate (cAMP) upon withdrawal. This cellular phenomenon ... -
Copresence of High-Risk Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer: A Tissue Microarray and Molecular Study from Lebanon
Nagi, Karim; Gupta, Ishita; Jurdi, Nawaf; Yasmeen, Amber; Vranić, Semir; Batist, Gerald; Al Moustafa, Ala-Eddin... more authors ... less authors ( MDPI , 2021 , Article)Colorectal cancer (CRC) is the third most common cause of cancer-related deaths worldwide. Human papillomaviruses (HPVs) and Epstein–Barr virus (EBV) have been reported to be present in different types of human cancers ... -
High-risk human papillomaviruses and Epstein-Barr virus in breast cancer in Lebanese women and their association with tumor grade: a molecular and tissue microarray study.
Nagi, Karim; Gupta, Ishita; Jurdi, Nawaf; Jabeen, Ayesha; Yasmeen, Amber; Batist, Gerald; Vranic, Semir; Al-Moustafa, Ala-Eddin... more authors ... less authors ( BMC , 2021 , Article)High-risk human papillomaviruses (HPVs) are present and can cooperate with Epstein-Barr virus (EBV) to initiate and/or enhance the progression of several types of human carcinomas including cervical as well as head and ... -
How can we improve the measurement of receptor signaling bias?
Nagi, Karim ( Taylor & Francis Group , 2023 , Article)G protein-coupled receptors (GPCRs) are flexible and dynamic signaling entities that can adopt multiple active conformations upon activation [Citation1,Citation2]. However, each agonist stabilizes a distinct receptor ... -
Signaling diversity of mu- and delta- opioid receptor ligands: Re-evaluating the benefits of β-arrestin/G protein signaling bias.
Pineyro, Graciela; Nagi, Karim ( Elsevier , 2020 , Article)Opioid analgesics are elective for treating moderate to severe pain but their use is restricted by severe side effects. Signaling bias has been proposed as a viable means for improving this situation. To exploit this ... -
Vitamin D and Its Potential Interplay With Pain Signaling Pathways
Habib, Abdella M; Nagi, Karim; Thillaiappan, Nagendra Babu; Akhtar, Saghir; vijayakumar, sukumaran ( Frontiers Media , 2020 , Article Review)About 50 million of the U.S. adult population suffer from chronic pain. It is a complex disease in its own right for which currently available analgesics have been deemed woefully inadequate since ~20% of the sufferers ...