Browsing College of Medicine by Title
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Retinoids and Reactive Oxygen Species in Cancer Cell Death and Therapeutics
( Springer Nature , 2022 , Book chapter)Retinoids are a large family of structurally related natural and synthetic molecules that exhibit a variety of effects in embryogenesis and adult life. The parent compound of retinoids is vitamin A which was first discovered ... -
Retraction to: Samaha et al. effects of a single dose of ivermectin on viral and clinical outcomes in asymptomatic sars-cov-2 infected subjects: A pilot clinical trial in lebanon. viruses 2021, 13, 989
( MDPI , 2021 , Other)The journal retracts the article, Effects of a Single Dose of Ivermectin on Viral and Clinical Outcomes in Asymptomatic SARS-CoV-2 Infected Subjects: A Pilot Clinical Trial in Lebanon [1], cited above. Following publication, ... -
The retrospective study of the metabolic patterns of BCG-vaccination in type-2 diabetic individuals in COVID-19 infection
( Frontiers Media , 2023 , Article)Background: The cross-protective nature of Bacillus Calmette-Guerin (BCG) vaccine against SARS-CoV-2 virus was previously suggested, however its effect in COVID-19 patients with type 2 diabetes (T2D) and the underlying ... -
Reversal of insulin resistance in overweight and obese subjects by trans-resveratrol and hesperetin combination—link to dysglycemia, blood pressure, dyslipidemia, and low-grade inflammation
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)The dietary supplement, trans-resveratrol and hesperetin combination (tRES-HESP), induces expression of glyoxalase 1, countering the accumulation of reactive dicarbonyl glycating agent, methylglyoxal (MG), in overweight ... -
Review of Post-translational Modification of Human Serum Albumin
( Bentham , 2022 , Article)Post-translational modifications (PTMs) may affect the functions of human serum albumin. Here we review reports of novel PTMs of human serum albumin. This study reviewed one hundred twenty-three recently reported novel ... -
Revolutionizing chronic lymphocytic leukemia diagnosis: A deep dive into the diverse applications of machine learning
( Elsevier , 2023 , Article)Chronic lymphocytic leukemia (CLL) is a B cell neoplasm characterized by the accumulation of aberrant monoclonal B lymphocytes. CLL is the predominant type of leukemia in Western countries, accounting for 25% of cases. ... -
Risk of Depression and Suicide in Diabetic Patients.
( Springer , 2022 , Article)Although mental disorders in diabetics are more prevalent than in the general population, an increased prevalence of depression, frequently leading to suicide, has been reported in individuals with diabetes mellitus. ... -
The risk of developing major depression among individuals with subthreshold depression: a systematic review and meta-analysis of longitudinal cohort studies.
( Cambridge University Press , 2019 , Article)Studies have consistently shown that subthreshold depression is associated with an increased risk of developing major depression. However, no study has yet calculated a pooled estimate that quantifies the magnitude of this ... -
Risk Perception and Psychological Impact of COVID-19 Pandemic Among Healthcare Workers in Primary and Secondary Healthcare Settings in Qatar: A National Study
( SAGE Publications Inc. , 2021 , Article)Introduction: During the coronavirus disease 2019 (COVID-19) pandemic, primary and secondary healthcare workers (HCWs) have faced unprecedented stress, jeopardizing their mental well-being. Aims: To compare risk perception ... -
Risk prediction of early decline in renal function in diabetic kidney disease with algorithm including fractional excretion of glycated amino acids
( Qatar University Press , 2021 , Poster)Background and aims: Diabetic kidney disease occurs in ca. 40% patients with diabetes. Approximately 1 in 5 patients with type 1 diabetes mellitus (T1DM) and 1 in 3 patients with type 2 diabetes mellitus (T2DM) develop ... -
RKIP in human diseases and its potential as a prognostic indicator and therapeutic target
( Elsevier , 2020 , Book chapter)The Raf kinase inhibitory protein (RKIP) is an inhibitor of the RAF/MEK/ERK and NF-κB signaling pathways, through which it regulates several key processes of the cell's physiology, such as its proliferation, motility and ... -
Robotic Inguinal Hernia Repair and Obesity, Where Do We Stand?
( Mary Ann Liebert Inc. , 2022 , Article)Introduction: Robotic hernia repair is an established modality; we aimed to assess the safety and efficacy in obese patients. Methods: A retrospective cross-control study was conducted on the results for 99 patients who ... -
Robotic inguinal hernia repair: systematic review and meta-analysis
( John Wiley and Sons Inc , 2021 , Article Review)Background: We aimed to conduct a systematic review and meta-analysis of RHR's efficiency and safety, in addition to comparison between open and laparoscopic techniques. Methods: A literature review was conducted from 2000 ... -
The robust error meta-regression method for dose-response meta-analysis.
( Lippincott, Williams & Wilkins , 2018 , Article)Dose-response meta-analysis has been widely employed in evidence-based decision-making. Currently, the most popular approach is the one or two-stage generalized least squares for trend model. This approach however has some ... -
Role and Significance of c-KIT Receptor Tyrosine Kinase in Cancer: A Review.
( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2022 , Article Review)c-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK) that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell proliferation, survival, and migration and is ... -
The Role of Apolipoproteins in the Commonest Cancers: A Review
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Apolipoproteins (APOs) are vital structural components of plasma lipoproteins that are involved in lipid metabolism and transport. Recent studies have reported an association between apolipoprotein dysregulation and the ... -
The Role of CCL21/CCR7 Chemokine Axis in Breast Cancer Progression
( MDPI , 2015 , Article Review)Tumor-induced lymphangiogenesis facilitates breast cancer progression by generating new lymphatic vessels that serve as conduits for tumor dissemination to lymph nodes and beyond. Given the recent evidence suggesting the ... -
Role of E2F transcription factor in oral cancer: Recent insight and advancements
( Elsevier , 2023 , Article)The family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating the expression of several genes related to ... -
The Role of Epstein-Barr Virus in Cervical Cancer: A Brief Update.
( Frontiers Media , 2018 , Article Review)Epstein-Barr virus (EBV) belongs to the group of gamma-herpes viruses and was the first recognized human oncovirus. EBV is responsible for infectious mononucleosis and multiple lymphoid and epithelial malignancies including ... -
Role of HMGB1 and its associated signaling pathways in human malignancies
( Elsevier , 2023 , Article)The High-Mobility Group Box-1 (HMGB1), a non-histone chromatin-associated protein, plays a crucial role in cancer growth and response to therapy as it retains a pivotal role in promoting both cell death and survival. HMGB1 ...