Browsing College of Medicine by Title
Now showing items 1186-1205 of 1358
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Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome
( Frontiers Media S.A. , 2021 , Article)Background: Tumor glycolysis is a target for cancer chemotherapy. Methylglyoxal (MG) is a reactive metabolite formed mainly as a by-product in anaerobic glycolysis, metabolized by glyoxalase 1 (Glo1) of the glyoxalase ... -
Subclavian pseudoaneurysm presenting as partially obstructed airway
(2023 , Article)We are presenting a noteworthy instance of managing the airway of a patient who had acute tracheal stenosis of considerable magnitude caused by external compression resulting from a large right subclavian pseudoaneurysm.Tracheal ... -
Subcutaneous emphysema, pneumothorax, pneumomediastinum and pneumoperitoneum after upper gastrointestinal endoscopy
( NLM (Medline) , 2020 , Article)Upper gastrointestinal (GI) endoscopies are performed for several reasons. The overuse of endoscopy has negative effects on the quality of healthcare and pressurises endoscopy services. It also results in the complications. ... -
Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways
( Elsevier , 2021 , Article)HER2-positive breast cancer is one of its most challenging subtypes, forming around 15–25% of the total cases. It is characterized by aggressive behavior and treatment resistance. On the other hand, poly (amidoamine) (PAMAM) ... -
Substantial toxic effect of water-pipe smoking on the early stage of embryonic development
( Oxford University Press , 2017 , Article)Water-pipe smoking (WPS) is the most widespread tobacco use in the Middle-East, and is rapidly spreading globally. Smoke from WP contains most of the compounds present in cigarette smoke, although in different proportions. ... -
Successful minimally invasive management of nonvascular grade IV blunt renal trauma with complete transection in a 7-year-old girl
( Elsevier , 2022 , Article)Non-operative treatment of high-grade renal trauma in hemodynamically stable children is gaining increasing acceptance nowadays. However, the management of isolated grade IV injuries, particularly those with complete renal ... -
A Successful Treatment of Encapsulating Peritoneal Sclerosis in an Adolescent Boy on Long-term Peritoneal Dialysis: A Case Report.
( First Faculty of Medicine Charles University , 2020 , Article)Encapsulating peritoneal sclerosis (EPS) is a rare life-threatening complication associated with peritoneal dialysis (PD). EPS is characterized by progressive fibrosis and sclerosis of the peritoneum, with the formation ... -
Suppressor capacity of iron nanoparticles biosynthesized using Salvia chloroleuca leaf aqueous extract on methadone-induced cell death in PC12: Formulation a new drug from relationship between the nanobiotechnology and neurology sciences
( Wiley , 2020 , Article)© 2020 John Wiley & Sons, Ltd. Metallic nanoparticles have gained significant attention in the area of biomedical technology. Because of its high surface area, metallic nanoparticles are being widely used in various ... -
Surgical management and outcomes of traumatic global brachial plexus injury: A concise review and our center approach
( Walter de Gruyter , 2023 , Article)Global brachial plexus injury (GBPI) mainly affects adults and causes severe life-changing consequences that lead to the deterioration of patients' quality of life. Several surgical approaches have been described and ... -
Surgical management of Encapsulating Peritoneal Sclerosis (EPS) in children: international case series and literature review.
( Springer , 2021 , Article)Encapsulating Peritoneal Sclerosis (EPS) is a rare phenomenon in paediatric patients with kidney failure treated with peritoneal dialysis (PD). This study highlights clinical challenges in the management of EPS, with ... -
Suspected Agomelatine-induced restless legs syndrome: a case report
( BioMed Central Ltd , 2021 , Article)Background: Restless Legs Syndrome (RLS) is a sensorimotor disorder characterized by unpleasant and distressing sensations in the lower limbs that are more pronounced in the evening, commence or worsen at rest, and show ... -
Suspended death: on freezing corpses and muting death of Palestinian women martyrs
( Taylor & Francis (Routledge) , 2018 , Article)During the 2015 Palestinian ‘al-Quds’ uprising, more than 80 Palestinians were killed and their corpses were held by Israel in freezers. Fifteen of these corpses belonged to women and girls. This article draws on ethnographic ... -
Synergistic antipruritic effects of gamma aminobutyric acid A and B agonists in a mouse model of atopic dermatitis
( Mosby Inc. , 2017 , Article)Background Despite recent insights into the pathophysiology of acute and chronic itch, chronic itch remains an often intractable condition. Among major contributors to chronic itch is dysfunction of spinal cord gamma ... -
Synthesis of evidence from zero-events studies: A comparison of one-stage framework methods
( John Wiley & Sons, Ltd , 2021 , Article)In evidence synthesis, dealing with zero-events studies is an important and complicated task that has generated broad discussion. Numerous methods provide valid solutions to synthesizing data from studies with zero-events, ... -
Synthesis of New Chromene Derivatives Targeting Triple-Negative Breast Cancer Cells
( MDPI , 2023 , Article)Breast cancer continues to be the leading cause of cancer-related deaths among women worldwide. The most aggressive type of breast cancer is triple-negative breast cancer (TNBC). Indeed, not only does TNBC not respond well ... -
Synthesis, characterization, and evaluation of cytotoxicity, antioxidant, antifungal, antibacterial, and cutaneous wound healing effects of copper nanoparticles using the aqueous extract of Strawberry fruit and L-Ascorbic acid
( Elsevier , 2020 , Article)© 2020 Elsevier Ltd Fragaria ananassa, also known as “Strawberry” is a common species in Iran and widely used for its anti-inflammatory, anti-ulcer, astringent, anti-allergic, antibacterial, antifungal, and antidiarrheal ... -
Systemic antibiotic sales and WHO recommendations, India.
( World Health Organization , 2022 , Article)To analyse sales of fixed-dose combination and single antibiotics in India in relation to World Health Organization (WHO) recommendations and national regulatory efforts to control antibiotic sales. We extracted data on ... -
Targeted and systemic insights into the crosstalk between DNA-dependent protein kinase catalytic subunit and receptors of estrogen, progesterone and epidermal growth factor in the context of cancer
( Springer , 2021 , Article)DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has emerged as a regulator of carcinogenesis. Increased expression of DNA-PKcs correlates with metastatic cancers. Here we review recently reported crosstalk of ... -
Targeted delivery of rifampicin to tuberculosis-infected macrophages: design, in-vitro, and in-vivo performance of rifampicin-loaded poly(ester amide)s nanocarriers
( Elsevier B.V. , 2016 , Article)We have developed a nano drug delivery system for the treatment of tuberculosis (TB) using rifampicin (RF) encapsulated in poly(ester amide)s nanoparticles (PEA-RF-NPs), which are biocompatible polymers. In this study, ... -
Targeted immunotherapy with a checkpoint inhibitor in combination with chemotherapy: A new clinical paradigm in the treatment of triple-negative breast cancer.
( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2019 , Article Review)The treatment of several solid and hematologic malignancies with immune checkpoint inhibitors (against PD-1/PD-L1) has dramatically changed the cancer treatment paradigm. However, no checkpoint inhibitors were previously ...