Browsing College of Medicine by Title
Now showing items 959-978 of 1357
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Perspectives of Persons With Type 2 Diabetes Toward Diabetes Self-Management: A Qualitative Study
( SAGE Publications , 2022 , Article)Background. The global increase in type 2 diabetes (T2D) poses a significant public health challenge worldwide. Due to the chronic and complex nature of the disease, management does not depend on pharmacotherapy alone; ... -
Pertussis toxin IgA testing over-diagnoses recent pertussis infection
( Elsevier , 2017 , Article)The importance of pertussis toxin (PT) IgA testing in the diagnosis of recent pertussis infection remains unclear. The contribution of PT IgA to the diagnosis of recent pertussis was reviewed in two separate analyses. ... -
The pharmaco-epigenetics of hypertension: a focus on microRNA
( Springer Nature , 2024 , Article)Hypertension is a major harbinger of cardiovascular morbidity and mortality. It predisposes to higher rates of myocardial infarction, chronic kidney failure, stroke, and heart failure than most other risk factors. By 2025, ... -
Pharmacologic inhibition of hypoxia-inducible factor (HIF)-hydroxylases ameliorates allergic contact dermatitis
( Blackwell Publishing Ltd , 2019 , Article)Background When an immune cell migrates from the bloodstream to a site of chronic inflammation, it experiences a profound decrease in microenvironmental oxygen levels leading to a state of cellular hypoxia. The hypoxia‐inducible ... -
Pharmacological and antioxidant activities of rhus coriaria l. (sumac)
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Rhus coriaria L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in ... -
Pharmacotherapy in COVID-19 patients: a review of ACE2-raising drugs and their clinical safety
( Taylor and Francis Ltd , 2020 , Article Review)The COVID-19 pandemic is caused by the severe acute-respiratory-syndrome-coronavirus-2 that uses ACE2 as its receptor. Drugs that raise serum/tissue ACE2 levels include ACE inhibitors (ACEIs) and angiotensin-II receptor ... -
Phenotypic switching of vascular smooth muscle cells in atherosclerosis, hypertension, and aortic dissection
( Wiley-Blackwell , 2024 , Article)Vascular smooth muscle cells (VSMCs) play a critical role in regulating vasotone, and their phenotypic plasticity is a key contributor to the pathogenesis of various vascular diseases. Two main VSMC phenotypes have been ... -
Phenylalanine derivatives with modulating effects on human α1-glycine receptors and anticonvulsant activity in strychnine-induced seizure model in male adult rats
( Elsevier B.V. , 2017 , Article)The critical role of α1-glycine receptor (α1-GLYRs) in pathological conditions such as epilepsy is well known. In the present study, structure-activity relations for a series of phenylalanine derivatives carrying selected ... -
Phospholipase C zeta and calcium oscillations at fertilisation: The evidence applications and further questions
( Elsevier Ltd , 2018 , Article)Oocyte activation is a fundamental event at mammalian fertilisation, initiated by a series of characteristic calcium (Ca2+) oscillations in mammals. This characteristic pattern of Ca2+ release is induced in a species-specific ... -
Phospholipase C zeta profiles are indicative of optimal sperm parameters and fertilisation success in patients undergoing fertility treatment.
( wiley , 2020 , Article)Oocyte activation is driven by intracellular calcium (Ca ) oscillations induced by sperm-specific PLCζ, abrogation of which causes oocyte activation deficiency in humans. Clinical PLCζ investigations have been limited to ... -
Physical activity in pregnancy prevents gestational diabetes: A meta-analysis
( Elsevier , 2020 , Article)AimsThe effectiveness of physical activity (PA) programs for prevention of gestational diabetes (GDM) lacks conclusive evidence. The aim of this study was to generate clear evidence regarding the effectiveness of physical ... -
Physicians should build their own machine-learning models
( Elsevier , 2024 , Other)Yosra Mekki suggests that doctors should have the ability to develop their own machine-learning models. She proposes an approach with the "spotlight" on physicians, to create user-friendly frameworks that allow doctors to ... -
Physiological Intracranial Calcifications in Children A computed tomography-based study
( Sultan Qaboos University , 2023 , Article)Objectives: This study aimed to examined the frequency of physiological intracranial calcifications (PICs) in paediatric population using computed tomography (CT). Methods: The brain CT scans of consecutive patients (age ... -
Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Alzheimer’s Disease?
( Springer Singapore , 2022 , Book chapter)Alzheimer’s disease (AD) is a debilitating neurodegenerative disease with devastating outcomes to patients and exhaustive burdens to healthcare systems. Alzheimer’s disease has always been the focus of extensive research ... -
Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Traumatic Brain Injury?
( Springer Singapore , 2022 , Book chapter)Traumatic brain injury (TBI) is one of the key causes of deaths and disabilities worldwide. TBI progresses in two phases. The primary phase of injury is the direct result of the physical damage caused by the external force ... -
Pilot Evaluation of the “Practice Educators’ Academy” Preceptor Development Program for Continuing Health Professional Education Programs in Qatar
( Qatar University Press , 2021 , Poster)"The Practice Educators' Academy Program" is an innovative educational intervention developed following a preceptor-focused needs assessment. This study evaluated the program's effect on self-efficacy and knowledge amongst ... -
A Pilot Randomized Controlled Trial of De Novo Belatacept-based Immunosuppression After Lung Transplantation.
( Wolters Kluwer Health , 2024 , Article)Chronic lung allograft dysfunction (CLAD) is the leading cause of death beyond the first year after lung transplantation. The development of donor-specific antibodies (DSA) is a recognized risk factor for CLAD. Based on ... -
Platelet thromboxane inhibition by low-dose aspirin in polycythemia vera: Ex vivo and in vivo measurements and in silico simulation
( Wiley , 2022 , Article)Low-dose aspirin is currently recommended for patients with polycythemia vera (PV), a myeloproliferative neoplasm with increased risk of arterial and venous thromboses. Based on aspirin pharmacodynamics in essential ... -
Platelet–Neutrophil Association in NETs-Rich Areas in the Retrieved AIS Patient Thrombi
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Histological structure of thrombi is a strong determinant of the outcome of vascular recanalization therapy, the only treatment option for acute ischemic stroke (AIS) patients. A total of 21 AIS patients from this study ... -
Pleiotropic properties of statins via angiogenesis modulation in cardiovascular disease
( Elsevier , 2022 , Article)Inhibition of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase by statins is affected by inhibiting the active site of the enzyme in a competitive manner. Statins reduce plasma cholesterol by inhibiting its de novo ...