Browsing College of Medicine by Publisher "Blackwell Publishing Ltd"
Now showing items 1-10 of 10
-
Cell shortening and calcium dynamics in epicardial and endocardial myocytes from the left ventricle of Goto-Kakizaki type 2 diabetic rats
( Blackwell Publishing Ltd , 2018 , Article)New Findings: What is the central question of this study? To investigate haemodynamic dysfunction in the type 2 diabetic Goto-Kakizaki (GK) rat, we measured shortening and Ca2+ transport in ventricular myocytes from ... -
COVID-19 vaccine hesitancy and attitudes in Qatar: A national cross-sectional survey of a migrant-majority population
( Blackwell Publishing Ltd , 2021 , Article)Background: Vaccine hesitancy is a global threat undermining control of preventable infections. Emerging evidence suggests that hesitancy to COVID-19 vaccination varies globally. Qatar has a unique population with around ... -
Digenic inheritance and genetic modifiers
( Blackwell Publishing Ltd , 2018 , Article Review)Digenic inheritance (DI) concerns pathologies with the simplest form of multigenic etiology, implicating more than 1 gene (and perhaps the environment). True DI is when biallelic or even triallelic mutations in 2 distinct ... -
Generalisability theory analyses of concept mapping assessment scores in a problem-based medical curriculum
( Blackwell Publishing Ltd , 2016 , Article)Context In problem-based learning (PBL), students construct concept maps that integrate different concepts related to the PBL case and are guided by the learning needs generated in small-group tutorials. Although an ... -
House dust mite-treated PAR2 over-expressor mouse: A novel model of atopic dermatitis
( Blackwell Publishing Ltd , 2019 , Article)Background Atopic dermatitis (AD) is a complex skin disease involving causative effects from both intrinsic and extrinsic sources. Murine models of the disease often fall short in one of these components and, as a result, ... -
Interleukin-4 and interleukin-13 evoke scratching behaviour in mice
( Blackwell Publishing Ltd , 2019 , Article)Persistent and relapsing itch commonly manifests in inflammatory skin disorders such as atopic dermatitis (AD). AD pathogenesis is driven by interleukin-4 (IL-4) and interleukin-13 (IL-13). Dupilumab, a monoclonal antibody ... -
Lichen planus: a comprehensive evidence-based analysis of medical treatment
( Blackwell Publishing Ltd , 2019 , Article Review)Lichen planus (LP) is a chronic-relapsing inflammatory skin disease. Although many drugs have been used for the management of LP, some of them lack the backup by strong therapeutic evidence, while others are not suitable ... -
Mutations in PLCδ1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function
( Blackwell Publishing Ltd , 2016 , Article)Hereditary leukonychia is a rare genetic nail disorder characterized by distinctive whitening of the nail plate of all 20 nails. Hereditary leukonychia may exist as an isolated feature, or in simultaneous occurrence with ... -
Pharmacologic inhibition of hypoxia-inducible factor (HIF)-hydroxylases ameliorates allergic contact dermatitis
( Blackwell Publishing Ltd , 2019 , Article)Background When an immune cell migrates from the bloodstream to a site of chronic inflammation, it experiences a profound decrease in microenvironmental oxygen levels leading to a state of cellular hypoxia. The hypoxia‐inducible ... -
Role of mast cells and basophils in pruritus
( Blackwell Publishing Ltd , 2018 , Article Review)To protect our body systems, there is a constant interactive conversation between the skin nervous and immune system. Important elements of this conversation in the skin include mast cells, basophils, and sensory nerve ...