Browsing College of Medicine by Publisher "Elsevier Ltd"
Now showing items 1-19 of 19
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Antibody-Dependent Enhancement (ADE) and the role of complement system in disease pathogenesis
( Elsevier Ltd , 2022 , Article Review)Antibody-dependent enhancement (ADE) has been associated with severe disease outcomes in several viral infections, including respiratory infections. In vitro and in vivo studies showed that antibody-response to SARS-CoV ... -
Assessment of PULP score in predicting 30-day perforated duodenal ulcer morbidity, and comparison of its performance with Boey and ASA, a retrospective study
( Elsevier Ltd , 2019 , Article)Background: /aim: Scores commonly employed to risk stratify perforated peptic ulcer patients include ASA (American Society of Anesthesiologists), Boey and peptic ulcer perforation score (PULP). However, few studies assessed ... -
Comprehensive analysis of cancers of unknown primary for the biomarkers of response to immune checkpoint blockade therapy
( Elsevier Ltd , 2018 , Article)Background: Cancer of unknown primary (CUP) accounts for approximately 3% of all malignancies. Avoiding immune destruction is a major cancer characteristic and therapies aimed at immune checkpoint blockade are in use for ... -
Curcumin potentiates the function of human ? 7 -nicotinic acetylcholine receptors expressed in SH-EP1 cells
( Elsevier Ltd , 2018 , Article)Effects of curcumin, a biologically active ingredient of turmeric, were tested on the Ca 2+ transients induced by the activation of ? 7 subunit of the human nicotinic acetylcholine (? 7 nACh) receptor expressed in SH-EP1 ... -
Cytokine responses in campylobacteriosis: Linking pathogenesis to immunity
( Elsevier Ltd , 2018 , Article Review)Campylobacter jejuni is an important enteric pathogen that causes diarrheas of different degrees of severity and several extra-intestinal manifestations, including Guillain-Barre syndrome. The variability of disease outcomes ... -
Dimensions around the nutrient foramina of the tibia and fibula in the estimation of sex
( Elsevier Ltd , 2018 , Article)© 2018 Elsevier B.V. Sex estimation from skeletal remains is one of the key components in establishing a biological profile and consequent identification of an individual in a forensic and medico-legal practice. The use ... -
Economic burden of infectious diseases and its equity implications in Indian households: Estimates from a nationally representative household survey (2017–18)
( Elsevier Ltd , 2024 , Article)Infectious diseases remain one of the major causes of health and economic burden for Indian households. Furthermore, the magnitude of economic losses on account of infectious disease episodes varies widely across rich and ... -
Expression of sperm PLC? and clinical outcomes of ICSI-AOA in men affected by globozoospermia due to DPY19L2 deletion
( Elsevier Ltd , 2018 , Article)Globozoospermia is characterized by the presence of 100% acrosomeless round-headed spermatozoa in an ejaculate. Failed fertilization after intracytoplasmic sperm injection (ICSI) is commonly reported for globozoospermic ... -
First sliding Amyand hernia harbouring appendicular schistosomiasis: Case report
( Elsevier Ltd , 2019 , Article)Introduction: Amyand's hernia (AH) is rare, schistosomiasis of the appendix is very uncommon, and both conditions coexisting together is an extremely rare event. Pre-operative diagnosis of each of the two conditions is ... -
Gallbladder cancer: 7-Year experience from Qatar
( Elsevier Ltd , 2019 , Article)Thirty-five patients presented with GC during the study period, 10 females (28.6%) and 25 males (71.4%). Fourteen patients (40%) were diagnosed incidentally after laparoscopic cholecystectomy, 16 (48.6%) were diagnosed ... -
Lorcaserin vs. Phentermine among non-surgical and surgical obese patients: Anthropometric, glycemic, lipid, safety and cost outcomes
( Elsevier Ltd , 2019 , Article)Background To evaluate effectiveness, safety, and costs of Lorcaserin vs. phentermine among obese non–surgical and surgical patients (post bariatric surgery). Methods This retrospective study retrieved charts of all ... -
Measurements of the talus in the assessment of population affinity
( Elsevier Ltd , 2018 , Article)© 2018 Elsevier B.V. As part of their routine work, forensic anthropologists are expected to report population affinity as part of the biological profile of an individual. The skull is the most widely used bone for the ... -
Mesoporous silica coated carbon nanofibers reduce embryotoxicity via ERK and JNK pathways
( Elsevier Ltd , 2021 , Article)Carbon nanofibers (CNFs) have been implicated in biomedical applications, yet, they are still considered as a potential hazard. Conversely, mesoporous silica is a biocompatible compound that has been used in various ... -
Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity
( Elsevier Ltd , 2019 , Article)The study of rare families with inherited pain insensitivity can identify new human-validated analgesic drug targets. Here, a 66-yr-old female presented with nil requirement for postoperative analgesia after a normally ... -
Nociceptor subtypes and their incidence in rat lumbar dorsal root ganglia (DRGs): focussing on C-polymodal nociceptors, A?-nociceptors, moderate pressure receptors and their receptive field depths
( Elsevier Ltd , 2019 , Article Review)A recent study with Ca++-sensitive-dyes in neurons in whole DRGs (Table 5) found that much lower percentages of nociceptors were polymodal-nociceptors (PMNs) (Emery et al., 2016), than the 50–80% values in many ... -
Phospholipase C zeta and calcium oscillations at fertilisation: The evidence applications and further questions
( Elsevier Ltd , 2018 , Article)Oocyte activation is a fundamental event at mammalian fertilisation, initiated by a series of characteristic calcium (Ca2+) oscillations in mammals. This characteristic pattern of Ca2+ release is induced in a species-specific ... -
Rare presentation of primary varicella zoster as fatal fulminant hepatitis in adult on low-dose,short-term steroid: Case report
( Elsevier Ltd , 2019 , Article)Background Varicella zoster virus presents clinically as primary (chickenpox) or secondary (herpes zoster) infection. Cutaneous and extracutaneous dissemination may occur, usually in immunocompromised patients. VZV ... -
Towards a better understanding of self-management interventions in type 2 diabetes: A concept analysis
( Elsevier Ltd , 2022 , Article)Objectives: Diabetes self-management educational (DSME) interventions can vary considerably, and it is unclear what is the operational conceptualization of the ideal delivery to individuals with type 2 diabetes (T2D). ... -
Towards a better understanding of self-management interventions in type 2 diabetes: A meta-regression analysis
( Elsevier Ltd , 2021 , Article)Aims: Attributes that operationally conceptualize diabetes self-management education (DSME) interventions have never been studied previously to assess their impact on relevant outcomes of interest in people with type 2 ...