Search
Now showing items 31-40 of 75
Use of conditional estimates of effect in cancer epidemiology: An application to lung cancer treatment
(
Elsevier
, 2024 , Article)
Background: In oncology clinical trials, there is the assumption that randomization sufficiently balances confounding covariates and therefore average treatment effects are usually reported. This paper explores the wider ...
Comparison of bias adjustment in meta-analysis using data-based and opinion-based methods.
(
Wolters Kluwer Health
, 2024 , Article)
Several methods exist for bias adjustment of meta-analysis results, but there has been no comprehensive comparison with unadjusted methods. We compare 6 bias-adjustment methods with 2 unadjusted methods to examine how these ...
Interruption of perivascular and perirenal adipose tissue thromboinflammation rescues prediabetic cardioautonomic and renovascular deterioration
(
Portland Press Ltd
, 2024 , Article)
The cardiovascular and renovascular complications of metabolic deterioration are associated with localized adipose tissue dysfunction. We have previously demonstrated that metabolic impairment delineated the heightened ...
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
(
Medicinska Naklada Zagreb
, 2024 , Article)
Uterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavo-rable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, ...
Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria
(
Portland Press Ltd
, 2024 , Article)
Homocystinuria is a rare disease caused by mutations in the CBS gene that results in a deficiency of cystathionine β-synthase (CBS). CBS is an essential pyridoxal 50-phosphate (PLP)-dependent enzyme in the transsulfuration ...
Integrated health system intervention aimed at reducing type 2 diabetes risk in women after gestational diabetes in South Africa (IINDIAGO): A randomised controlled trial protocol
(
BMJ Publishing Group
, 2024 , Article)
Introduction South Africa has a high prevalence of gestational diabetes mellitus (GDM; 15%) and many of these women (48%) progress to type 2 diabetes mellitus (T2DM) within 5 years post partum. A significant proportion ...
Serum metabolic signatures for Alzheimer’s Disease reveal alterations in amino acid composition: a validation study
(
Springer
, 2024 , Article)
Introduction: Alzheimer’s Disease (AD) is complex and novel approaches are urgently needed to aid in diagnosis. Blood is frequently used as a source for biomarkers; however, its complexity prevents proper detection. The ...
Determining the conclusiveness of a meta-analysis.
(
Wolters Kluwer Health
, 2024 , Article)
The pursuit of conclusive evidence related to an unanswered foreground (decision-making) question has been the driving factor behind multiple ongoing and planned randomized controlled trials as well as meta-analyses. ...
Assessing the Burden of COVID‑19 among Children Aged 6‑14 Years in Karnataka, India: A Cross‑sectional Survey
(
Medknow Publications
, 2024 , Article)
Background: India experienced three coronavirus disease (COVID-19) waves, with the third attributed to the highly contagious Omicron variant. Before the national vaccination rollout for children above 6, understanding ...
Vitamin D status affects proteomic profile of HDL-associated proteins and inflammatory mediators in dyslipidemia
(
Elsevier
, 2024 , Article)
Vitamin D deficiency and dyslipidemia have substantial implications for human health globally. Vitamin D is essential for bone metabolism and immune modulation, and its insufficiency is linked to various chronic inflammatory ...