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New clinical approaches and emerging evidence on immune-checkpoint inhibitors as anti-cancer therapeutics: CTLA-4 and PD-1 pathways and beyond
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Begell House Inc.
, 2019 , Article)
The development of immune checkpoint blockers, primarily comprising the anti-PD-1/anti-PD-L1 and anti-CTLA-4 monoclonal antibodies, has formed the therapeutic landscape of quite a few different cancer types. In spite of ...
Molecular characterization of cancers with NTRK gene fusions
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Springer Nature
, 2019 , Article)
Targeted inhibitors of neurotropic tyrosine kinases are highly effective in selected patients with gene fusions involving NTRK1, NTRK2, or NTRK3. These fusions are consistently detected in rare cancer types (e.g., secretory ...
Selecting the best meta-analytic estimator for evidence-based practice: a simulation study.
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Lippincott, Williams & Wilkins
, 2019 , Article)
Studies included in meta-analysis can produce results that depart from the true population parameter of interest due to systematic and/or random errors. Synthesis of these results in meta-analysis aims to generate an ...
Critical appraisal of predatory journals in pathology.
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BMJ
, 2019 , Article)
Predatory journals refer to journals that recruit articles through aggressive marketing and spam emails, promising a quick, but not robust, review and fast open-access (OA) publication, thus compromising scholarly publishing ...
Acute psychosis and concurrent rhabdomyolysis unveiling diagnosis of hypothyroidism
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BMJ Publishing Group
, 2019 , Article)
Neuropsychiatric and muscular symptoms can develop as part of hypothyroidism. However, frank psychosis or rhabdomyolysis due to hypothyroidism are uncommon and have been reported rarely as the first presenting features of ...
It is all about patients' stories: Case-based learning in residents' education
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Hamad Medical Corporation
, 2019 , Article)
Background: Problem-based learning (PBL) is an inquiry-based learning strategy which is learner centered and facilitates group discussion and critical thinking. Case-based learning (CBL), which is a more guided approach ...
Prenatal alcohol exposure is associated with early motor, but not language development in a South African cohort
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Cambridge University Press
, 2019 , Article)
Objective:To investigate the association of prenatal alcohol exposure (PAE) and early neurodevelopment in the first 2 years of life, adjusting for maternal sociodemographic and psychosocial factors, in the Drakenstein Child ...
Proteomics of transforming growth factor ?1 (TGF ?1) signaling in 184A1 human breast epithelial cells suggests the involvement of casein kinase 2? in TGF ?1-dependent p53 phosphorylation at Ser392
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Morion LLC
, 2019 , Article)
Aim: Transforming growth factor ?1 (TGF ?1) is a potent regulator of breast tumorigenesis. It inhibits proliferation of carcinoma cells, but the strength of its inhibitory action varies for cells from benigh, non-metastatic ...
Primary vs Revisional Gastric Bypass for Weight Loss and Improvements in Comorbidities: Comparisons at Mid-term Follow-up
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Springer
, 2019 , Article)
Background: Revisional gastric bypass (R-RYGB) surgery is utilized for the management of inadequate weight loss or weight regain observed after some cases of bariatric surgeries. Data on the mid-term effectiveness of primary ...
Novel biomarkers for potential risk stratification of drug induced liver injury (DILI): A narrative perspective on current trends
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Lippincott Williams and Wilkins
, 2019 , Article)
Background:Drug induced liver injury (DILI) is an increasing cause of acute liver injury especially with increasing need for pharmacotherapy of widening comorbidities amongst our ever-aging population. Uncertainty however ...