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Comparison of the biomarkers for targeted therapies in primary extra-mammary and mammary Paget's disease.
(
Wiley Open Access
, 2020 , Article)
Primary Extra-mammary Paget's disease (EMPD) is a very rare cutaneous adenocarcinoma affecting anogenital or axillary regions. It is characterized by a prolonged course with recurrences and eventually distant metastatic ...
Pharmacologic inhibition of hypoxia-inducible factor (HIF)-hydroxylases ameliorates allergic contact dermatitis
(
Blackwell Publishing Ltd
, 2019 , Article)
Background
When an immune cell migrates from the bloodstream to a site of chronic inflammation, it experiences a profound decrease in microenvironmental oxygen levels leading to a state of cellular hypoxia. The hypoxia‐inducible ...
Immunomodulatory Effects of Vitamin D in Pregnancy and Beyond.
(
Frontiers Media
, 2019 , Article)
In addition to its role in calcium homeostasis and bone formation, a modulatory role of the active form of vitamin D on cells of the immune system, particularly T lymphocytes, has been described. The effects of vitamin D ...
Somatostatin receptor SSTR2A and SSTR5 expression in neuroendocrine breast cancer.
(
Elsevier
, 2019 , Article)
Neuroendocrine breast cancer (NEBC) is a group of rare tumors, which could benefit from therapy targeting the somatostatin receptors (SSTRs). In particular, SSTR2A and SSTR5 are potential targets given their consistent ...
Mucocele of the appendix presenting as an exacerbated chronic tubo-ovarian abscess: A case report and comprehensive review of the literature.
(
Lippincott, Williams & Wilkins
, 2019 , Article)
Appendiceal mucocele is a rare entity of mucinous cystic dilatation of the appendix. It has no typical clinical presentation and is considered a potentially premalignant condition. We present a case of accidental intraoperative ...
In honour of Professor Leaf Huang, recipient of the Journal of Drug Targeting's life-time achievement award for 2018
(
Taylor and Francis Ltd
, 2018 , Article)
[No abstract available]
Development of discriminant functions to estimate sex in upper limb bones for mixed ancestry South Africans
(
Elsevier
, 2019 , Article)
The Chartered Society of Forensic Sciences South Africa has one of the highest murder rates in the world, which is associated with an increasing number of unidentified individuals. Forensic anthropologists can assist in ...
Stature estimation from the femur and tibia in Black South African sub-adults
(
Elsevier
, 2017 , Article)
Stature estimation can play a role in the positive identification of unknown individuals and as such it is routinely assessed during the examination of adult remains. Unfortunately, this is not a standard procedure when ...
Characterization and assessment of potential microRNAs involved in phosphate-induced aortic calcification
(
Wiley-Liss Inc.
, 2018 , Article)
Medial artery calcification, a hallmark of type 2 diabetes mellitus and chronic kidney disease (CKD), is known as an independent risk factor for cardiovascular mortality and morbidity. Hyperphosphatemia associated with CKD ...
Sex estimation using dimensions around the nutrient foramen of the long bones of the arm and forearm in South Africans
(
Elsevier
, 2017 , Article)
South Africa has had an increase in rates of crime, interpersonal violence and homicide since the introduction of democracy in 1994. Forensic osteological standards was lacking for South Africans of different population ...