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Genome-wide polygenic score, clinical risk factors, and long-term trajectories of coronary artery disease
(
American Heart Association
, 2020 , Article)
OBJECTIVE: To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPSCAD) with lifetime trajectories of CAD risk, directly compare its predictive capacity to traditional risk factors, ...
Calmodulin Mutations Associated with Congenital Cardiac Disease Display Novel Biophysical and Biochemical Characteristics
(
Elsevier
, 2018 , Article)
Calmodulin (CaM) is a cytoplasmic multifunctional calcium (Ca2+)-binding messenger that interacts with the cardiac ryanodine receptor (RyR2), a large transmembrane Ca2+ channel that mediates Ca2+ release from the sarcoplasmic ...
Defective Interaction of Cam with RyR2 Cam-Binding Pocket Might Contribute to Arrhythmogenic Cardiac Disease
(
Elsevier
, 2020 , Article)
Ryanodine receptor 2 (RyR2) is a large transmembrane calcium (Ca2+) release channel that mediates Ca2 release from the sarcoplasmic reticulum to activate cardiac muscle contraction. Calmodulin (CaM) regulation of RyR2 is ...
The Impact of Sleeve Gastrectomy on Gastroesophageal Reflux Disease in Patients with Morbid Obesity: a letter to the editor
(
springer link
, 2022 , Article)
Sancho et al.’s recent report on the effect of laparoscopic sleeve gastrectomy (LSG) on the symptomatology of gastroesophageal reflux disease (GERD) was both interesting and timely [1]. Their finding of a significant ...