College of Medicine: Recent submissions
Now showing items 661-680 of 1514
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Effectiveness of the neutralizing antibody sotrovimab among high-risk patients with mild-to-moderate SARS-CoV-2 in Qatar
( Elsevier , 2022 , Article)ObjectivesTo estimate the real-world effectiveness of sotrovimab against severe, critical, or fatal COVID-19 in Qatar at a time in which most SARS-CoV-2 incidences occurred due to the BA.2 Omicron subvariant. MethodsWe ... -
Detection of Antinuclear Antibodies Targeting Intracellular Signal Transduction, Metabolism, Apoptotic Processes and Cell Death in Critical COVID-19 Patients
( Universita Cattolica del Sacro Cuore , 2022 , Article)Background and Objectives: The heterogeneity of the coronavirus disease of 2019 (COVID-19) lies within its diverse symptoms and severity, ranging from mild to lethal. Acute respiratory distress syndrome (ARDS) is a leading ... -
Characteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic Syndrome.
( Frontiers , 2022 , Article)Obesity-associated dysglycemia is associated with metabolic disorders. MicroRNAs (miRNAs) are known regulators of metabolic homeostasis. We aimed to assess the relationship of circulating miRNAs with clinical features in ... -
What is polypharmacy in people living with HIV/AIDS? A systematic review.
( springer link , 2022 , Article)Polypharmacy in people living with HIV/AIDS (PLWHA) is a rising morbidity that exacts hefty economic burden on health budgets in addition to other adverse clinical outcomes. Despite recent advances, uncertainty remains ... -
Platelet–Neutrophil Association in NETs-Rich Areas in the Retrieved AIS Patient Thrombi
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Histological structure of thrombi is a strong determinant of the outcome of vascular recanalization therapy, the only treatment option for acute ischemic stroke (AIS) patients. A total of 21 AIS patients from this study ... -
Combined Noncoding RNA-mRNA Regulomics Signature in Reprogramming and Pluripotency in iPSCs
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Somatic cells are reprogrammed with reprogramming factors to generate induced pluripotent stem cells (iPSCs), offering a promising future for disease modeling and treatment by overcoming the limitations of embryonic stem ... -
Mitigating Cardiotoxicity of Dendrimers: Angiotensin-(1-7) via Its Mas Receptor Ameliorates PAMAM-Induced Cardiac Dysfunction in the Isolated Mammalian Heart
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Aim: The influence of the physiochemical properties of dendrimer nanoparticles on cardiac contractility and hemodynamics are not known. Herein, we investigated (a) the effect of polyamidoamine (PAMAM) dendrimer generation ... -
Angry scientists, angry analysts and angry novelists
( Springer Nature , 2023 , Article)To the Editor: Professor Bonora has written a critique looking back at his career in diabetes research since the 1970s and we reflect on his critique by also looking back at our careers in clinical endocrinology (Professor ... -
Metabolic changes after surgical fat removal: Current gaps and suggestions for future studies
( Elsevier , 2023 , Article)Dear Editor, We read with interest the letter by Seretes et al. discussing the findings and limitations of our evidence synthesis regarding the metabolic implications of surgical subcutaneous fat removal (SSFR).1 It is ... -
Social determinants of depression among mid-to-older aged Australians: A prospective study of the effects of neighbourhood disadvantage and crime
( Elsevier , 2022 , Article)BackgroundFew studies examining social determinants of depression have incorporated area level objectively measured crime combined with self-report measures of perceived crime. How these factors may interrelate with ... -
Nano-targeting vascular remodeling in cancer: Recent developments and future directions
( Elsevier , 2022 , Article Review)Tumor growth and progression are strictly dependent on the adequate blood supply of oxygen and nutrients. The formation of new blood vessels and vascular networks is essential to ensure this demand. Blood vessels also ... -
Proteomic profile alterations in porcine conceptuses during early stages of development
( Elsevier , 2021 , Article)The dynamic embryo development during the early stages of gestation requires precise molecular changes, including proteomic ones. We aimed to find unique proteins for porcine conceptuses specifically during the peri-implantation ... -
Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
( Elsevier , 2023 , Article)Mice with ectopic expression of uncoupling protein-1 (UCP1) in skeletal muscle exhibit a healthy aging phenotype with increased longevity and resistance to impaired metabolic health. This may be achieved by decreasing ... -
Protein glycation – biomarkers of metabolic dysfunction and early-stage decline in health in the era of precision medicine
( Elsevier , 2021 , Article)Protein glycation provides a biomarker in widespread clinical use, glycated hemoglobin HbA1c (A1C). It is a biomarker for diagnosis of diabetes and prediabetes and of medium-term glycemic control in patients with established ... -
Editorial: The effect of COVID-19 on hematological disease diagnosis, management and outcomes
( Frontiers Media S.A. , 2023 , Article)Lee, Chieng, Lau et al. studied the effects of coronavirus disease-2019 (COVID-19) on the clinical presentation, radiological findings, and outcomes of the infection in patients with hemoglobinopathies. They found that the ... -
Effect of BPA on CYP450s expression, and nicotine modulation, in fetal rat brain
( Elsevier , 2022 , Article)Human exposure to bisphenol A (BPA) is mainly due to migration from plastic packaging into food and beverages. Studies reported BPA endocrine disruptions through interactions with different nuclear receptors, including the ... -
The effect of clopidogrel and aspirin on the severity of traumatic brain injury in a rat model
( Elsevier , 2022 , Article)Traumatic Brain Injury (TBI) is one of the leading causes of death and disability worldwide. Aspirin (ASA) and clopidogrel (CLOP) are antiplatelet agents that inhibit platelet aggregation. They are implicated in worsening ... -
Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases
( Elsevier , 2021 , Article)Cardiovascular disease (CVD) is the leading cause of death worldwide. A search for more effective treatments of CVD is increasingly needed. Major advances in nanotechnology opened new avenues in CVD therapeutics. Owing to ... -
Enteric pathogens modulate metabolic homeostasis in the Drosophila melanogaster host
( Elsevier , 2022 , Article)On quotidian basis, living beings work out an armistice with their microbial flora and a scuffle with invading pathogens to maintain a normal state of health. Although producing virulence factors and escaping the host's ... -
Ultrasound Intima-Media Complex (IMC) Segmentation Using Deep Learning Models
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Common carotid intima-media thickness (CIMT) is a common measure of atherosclerosis, often assessed through carotid ultrasound images. However, the use of deep learning methods for medical image analysis, segmentation and ...
