College of Medicine: Recent submissions
Now showing items 81-100 of 1676
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Oncoproteins E6/E7 of the human papillomavirus types 16 & 18 synergize in modulating oncogenes and tumor suppressor proteins in colorectal cancer
( Taylor and Francis Ltd. , 2025 , Article)Objective Our study presents a novel analysis of the oncogenes and tumor suppressor proteins directly modulated by E6/E7 of high-risk HPV types 16 and 18, in colorectal cancer (CRC). Methods HCT 116 (KRAS mutant) & ... -
Targeting GSK-3β for adipose dysfunction and cardiovascular complications of metabolic disease: An entangled WNT/β-catenin question
( John Wiley and Sons Inc , 2024 , Article Review)Individuals with metabolic syndrome have a high risk of developing cardiovascular disorders that is closely tied to visceral adipose tissue dysfunction, as well as an altered interaction between adipose tissue and the ... -
Development and Validation of a Class Imbalance-Resilient Cardiac Arrest Prediction Framework Incorporating Multiscale Aggregation, ICA and Explainability
( IEEE Computer Society , 2024 , Article)Objective: Despite advancements in artificial intelligence (AI) for predicting cardiac arrest (CA) with multivariate time-series vital signs data, existing models continue to face significant problems, particularly concerning ... -
Prevalence of Antimicrobial Resistance Among the WHO's AWaRe Classified Antibiotics Used to Treat Urinary Tract Infections in Diabetic Women
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Background and Objectives: Diabetes is linked to a higher risk of urinary tract infections (UTIs) in women, often leading to recurrent antibiotic treatments. Frequent antibiotic use for UTIs can contribute to antimicrobial ... -
Association between 23 urinary VOC metabolites and cardiovascular disease among NHANES participants
( Routledge , 2025 , Article)This paper reports on the association between urine concentrations of Volatile Organic Compounds (UVOCs) metabolites and Cardiovascular Diseases (CVDs). This cross-sectional study uses a sample of participants from the ... -
Correlation analysis of global sagittal alignment of the spine in cases of low-grade degenerative lumbar spondylolisthesis
( Springer Science and Business Media Deutschland GmbH , 2025 , Article)Purpose: Disruptions in global sagittal spinal alignment can lead to changes in global sagittal spinal alignment, often manifesting as sagittal malalignment, where the trunk shifts forward. We proposed that these alignment ... -
Integrative Stacking Machine Learning Model for Small Cell Lung Cancer Prediction Using Metabolomics Profiling
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Background: Small cell lung cancer (SCLC) is an extremely aggressive form of lung cancer, characterized by rapid progression and poor survival rates. Despite the importance of early diagnosis, the current diagnostic ... -
Selective Colocalization of GHSR and GLP-1R in a Subset of Hypothalamic Neurons and Their Functional Interaction
( Oxford University Press , 2024 , Article)The GH secretagogue receptor (GHSR) and the glucagon-like peptide-1 receptor (GLP-1R) are G protein-coupled receptors with critical, yet opposite, roles in regulating energy balance. Interestingly, these receptors are ... -
Effect of DOPA decarboxylase inhibitor supplements on the incidence of urinary tract infections in Parkinson's disease patients: A systematic review and meta-analysis of randomized controlled trials
( Page Press Publications , 2024 , Article)Objectives: Parkinson's disease is the most common neurodegenerative disease. Combining levodopa with other drugs, including decarboxylase inhibitors (DCI) is its most effective treatment. Urinary tract infection (UTI) is ... -
Tofersen for SOD1 amyotrophic lateral sclerosis: a systematic review and meta-analysis
( Springer-Verlag Italia s.r.l. , 2025 , Article Review)Objective: Tofersen, an antisense oligonucleotide, has recently received FDA and EMA approval for treating amyotrophic lateral sclerosis (ALS) in adults with SOD1 gene mutations. This systematic review and meta-analysis ... -
Phonocardiogram classification based on 1D CNN with pitch-shifting and signal uniformity techniques
( European Signal Processing Conference, EUSIPCO , 2024 , Conference)This study combines 1D CNN with advanced signal processing to enhance heart sound classification, presenting three key contributions. Initially, we used a pitch-shifting technique to expand the dataset by altering ... -
The burden of diseases, injuries, and risk factors by state in the USA, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021
( Elsevier , 2024 , Article)Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides a comprehensive assessment of health and risk factor trends at global, regional, national, and subnational levels. This study ... -
Peripheral inflammatory and metabolic markers as potential biomarkers in treatment-resistant schizophrenia: Insights from a Qatari Cohort
( Elsevier , 2025 , Article)Schizophrenia presents significant diagnostic and treatment challenges, particularly in distinguishing between treatment-resistant (TRS) and non-treatment-resistant schizophrenia (NTRS). This cross-sectional study analyzed ... -
Automated detection of posterior urethral valves in voiding cystourethrography images: A novel AI-Based pipeline for enhanced diagnosis and classification
( Elsevier , 2025 , Article)Introduction: Posterior Urethral Valves (PUV) are rare congenital anomalies of the male urinary tract that can lead to urethral obstruction and increased risk of kidney disease. Traditional diagnosis relies on subjective ... -
Cigarette smoke extract induces p38-mediated expression and ROS/rho-mediated translocation of alpha 2C adrenoceptor in human microvascular smooth muscle cells
( Elsevier , 2025 , Article)Raynaud's phenomenon (RP) is a vascular disease characterized by exaggerated vasoconstriction in response to stressors, mainly cold and emotional stress. This vasoconstriction is mediated solely by alpha 2C-adrenoceptors ... -
GATA3: Orchestrating cellular fate through differentiation and proliferation
( Elsevier , 2025 , Article Review)Cell proliferation and differentiation are two fundamental biological processes that occur in biological systems, tightly regulated by various factors such as transcription factors (TFs). Zinc finger proteins are TFs ... -
Towards secure and trusted AI in healthcare: A systematic review of emerging innovations and ethical challenges
( Elsevier , 2025 , Article Review)Introduction: Artificial Intelligence is in the phase of health care, with transformative innovations in diagnostics, personalized treatment, and operational efficiency. While having potential, critical challenges are ... -
Women with persistent/recurrent vaginal discharge should be offered multiplex-7 PCR testing
( Elsevier , 2025 , Article)Background: Recurrent vaginal discharge is an important cause of repeated visits to the gynaecologists. Failure to correctly identify the causative organism with standard microscopy and culture techniques results in repeated ... -
Ethical dilemmas surrounding patients' "unwise" treatment preferences and suboptimal decision quality: case series of three renal cell carcinoma patients who developed local recurrences after non-guideline-concordant care choices
( African Field Epidemiology Network , 2024 , Article)Patient engagement and shared decision-making (SDM) between patients and clinicians is the foundation of patient-centered care. It aims to reach a treatment option that fits the patient's preference and is guideline-concordant. ... -
A Meta-Analysis of the Global Stillbirth Rates during the COVID-19 Pandemic
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)COVID-19 has been shown to have variable adverse effects on pregnancy. Reported data on stillbirth rates during the pandemic have, however, been inconsistent—some reporting a rise and others no change. Knowing the precise ...
