College of Medicine: Recent submissions
Now showing items 861-880 of 1820
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Doctors’ challenges during infectious disease outbreaks: Medical education insights from realistic fiction movies
( taylor and francis , 2021 , Article)Background: Movies have a strong influence on public perceptions due to their popularity and accessibility. Hence, movies on healthcare providers in general and medical doctors in particular can affect public opinions, ... -
Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer
( BMJ Publishing Group , 2020 , Article)Introduction Patients with diabetes have increased risk of periodontal disease, with increased risk of weakening of periodontal ligament and tooth loss. Periodontal ligament is produced and maintained by periodontal ligament ... -
Subcutaneous emphysema, pneumothorax, pneumomediastinum and pneumoperitoneum after upper gastrointestinal endoscopy
( NLM (Medline) , 2020 , Article)Upper gastrointestinal (GI) endoscopies are performed for several reasons. The overuse of endoscopy has negative effects on the quality of healthcare and pressurises endoscopy services. It also results in the complications. ... -
Worsening baroreflex sensitivity on progression to type 2 diabetes: Localized vs. systemic inflammation and role of antidiabetic therapy
( American Physiological Society , 2020 , Article)Cardiac autonomic neuropathy (CAN) is an early cardiovascular manifestation of type 2 diabetes (T2D) that constitutes an independent risk factor for cardiovascular mortality and morbidity. Nevertheless, its underlying ... -
Dysregulation of angiotensin converting enzyme 2 expression and function in comorbid disease conditions possibly contributes to coronavirus infectious disease 2019 complication severity
( American Society for Pharmacology and Experimental Therapy , 2021 , Article Review)ACE2 has emerged as a double agent in the COVID-19 ordeal, as it is both physiologically protective and virally conducive. The identification of ACE2 in as many as 72 tissues suggests that extrapulmonary invasion and damage ... -
Modulatory Effect of Intermittent Fasting on Adipose Tissue Inflammation: Amelioration of Cardiovascular Dysfunction in Early Metabolic Impairment
( Frontiers , 2021 , Article)Cardiometabolic syndrome (CMS) is a cluster of maladaptive cardiovascular, renal, thrombotic, inflammatory, and metabolic disorders. It confers a high risk of cardiovascular mortality and morbidity. CMS is triggered by ... -
Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity
( Springer Nature , 2020 , Article)Synucleinopathies including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) are characterized by pathological accumulation of α-synuclein (α-syn). Amongst the various approaches ... -
Bibliometric analysis of adverse drug reactions and pharmacovigilance research activities in Nepal
( Sage , 2020 , Article)Background: Bibliometric analyses have been used previously to study the measures of quality and impact of research performed in several health-related areas such as adverse drug reactions (ADRs) and pharmacovigilance (PV), ... -
Clinical characteristics of 51,815 patients presenting with positive and negative SARS-CoV-2 swab results in primary health care settings: Priority populations for vaccination
( Elsevier , 2021 , Article)We read with interest Brendish et al. study on the comparison between patients with SARS-CoV-2 positive and negative swab results.1 The study compared the clinical characteristics of adult hospitalised patients with ... -
Combination of Angiotensin (1-7) Agonists and Convalescent Plasma as a New Strategy to Overcome Angiotensin Converting Enzyme 2 (ACE2) Inhibition for the Treatment of COVID-19
( Frontiers , 2021 , Article)Coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently the most concerning health problem worldwide. SARS-CoV-2 infects cells by binding to ... -
Thrombosis Management and Challenges in COVID-19 Patients Presenting with Acute Coronary Syndromes.
( Medknow Publications , 2020 , Article)Thrombotic complications in patients with coronavirus disease 2019 (COVID-19) infection have been increasingly recognized, particularly those affecting the cardiovascular system. Patients with COVID-19 infection can suffer ... -
Could antigen presenting cells represent a protective element during sars-cov-2 infection in children?
( MDPI , 2021 , Article)Antigen Presenting Cells (APC) are immune cells that recognize, process, and present antigens to lymphocytes. APCs are among the earliest immune responders against an antigen. Thus, in patients with COVID-19, a disease ... -
The COVID-19 pandemic and healthcare systems in Africa: A scoping review of preparedness, impact and response
( BMJ Publishing Group , 2021 , Article)Background The COVID-19 pandemic has overwhelmed health systems in both developed and developing nations alike. Africa has one of the weakest health systems globally, but there is limited evidence on how the region is ... -
COVID-19 in Ethiopia: A geospatial analysis of vulnerability to infection, case severity and death
( BMJ Publishing Group , 2021 , Article)Background COVID-19 has caused a global public health crisis affecting most countries, including Ethiopia, in various ways. This study maps the vulnerability to infection, case severity and likelihood of death from COVID-19 ... -
Transforming growth factor-β1 inhibits interleukin-1β-induced expression of inflammatory genes and Cathepsin S activity in human vascular smooth muscle cells
( John Wiley and Sons Inc , 2021 , Article)Objective and design This study investigated the opposite mechanisms by which IL-1β and TGF-β1 modulated the inflammatory and migratory phenotypes in cultured human intimal vascular smooth muscle cells vSMCs. Materials ... -
Sex Differences in Cardiovascular Impact of Early Metabolic Impairment: Interplay between Dysbiosis and Adipose Inflammation
( American Society for Pharmacology and Experimental Therapy (ASPET) , 2022 , Article)The evolving view of gut microbiota has shifted toward describing the colonic flora as a dynamic organ in continuous interaction with systemic physiologic processes. Alterations of the normal gut bacterial profile, known ... -
Information on harm outcomes was insufficiently reported in systematic reviews and meta-analyses of individual participant data
( John Wiley and Sons Inc , 2021 , Article)Meta-analysis is an important tool for summarizing findings from scientific research. But for harm outcomes,issues may arise due to the distribution problems, zero-events problems, as well as low statistical power. Individual ... -
Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an in vivo mouse model
( Hindawi Limited , 2017 , Article)Cigarette smoking (S) is a risk factor for progressive chronic kidney disease, renal dysfunction, and renal failure. In this study, the effect of smoking on kidney function was investigated in a mouse model of myocardial ... -
Characterizing the Qatar advanced-phase SARS-CoV-2 epidemic
( springer nature , 2021 , Article)The overarching objective of this study was to provide the descriptive epidemiology of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Qatar by addressing specific research questions through a ... -
Morphometric Analysis of the Corpus Callosum According to Age and Sex in Middle Eastern Arabs: Racial Comparisons and Clinical Correlations to Autism Spectrum Disorder
( Frontiers Media S.A. , 2020 , Article)This study sought to examine the influence of age and sex on morphometric measurements of the corpus callosum (CC) within Middle Eastern Arab population, in order to obtain reference data and conduct racial comparisons ...
