College of Medicine: Recent submissions
Now showing items 501-520 of 1509
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Mitochondrial dysfunction and chronic inflammation in polycystic ovary syndrome
( MDPI , 2021 , Article Review)Polycystic ovarian syndrome (PCOS) is the most common endocrine–metabolic disorder affecting a vast population worldwide; it is linked with anovulation, mitochondrial dysfunctions and hormonal disbalance. Mutations in mtDNA ... -
Cardiac autonomic neuropathy: A progressive consequence of chronic low-grade inflammation in type 2 diabetes and related metabolic disorders
( MDPI , 2020 , Article Review)Cardiac autonomic neuropathy (CAN) is one of the earliest complications of type 2 diabetes (T2D), presenting a silent cause of cardiovascular morbidity and mortality. Recent research relates the pathogenesis of cardiovascular ... -
Therapeutic potential of resveratrol in covid-19-associated hemostatic disorders
( MDPI , 2021 , Article)Coagulation disorders, endotheliopathy and inflammation are the most common hallmarks in SARS-CoV-2 infection, largely determining COVID-19's outcome and severity. Dysfunctions of endothelial cells and platelets are tightly ... -
Effects of a single dose of ivermectin on viral and clinical outcomes in asymptomatic sars-cov-2 infected subjects: A pilot clinical trial in lebanon
( MDPI , 2021 , Article)Objective: This study was designed to determine the efficacy of ivermectin, an FDA-approved drug, in producing clinical benefits and decreasing the viral load of SARS-CoV-2 among asymptomatic subjects that tested positive ... -
Ace2 is an adjacent element of atherosclerosis and covid-19 pathogenesis
( MDPI , 2021 , Article Review)COVID-19 is a highly contagious new infection caused by the single-stranded RNA SarsCoV-2 virus. For the first time, this infection was recorded in December 2019 in the Chinese province of Wuhan. The virus presumably crossed ... -
Glycomic and Glycoproteomic Techniques in Neurodegenerative Disorders and Neurotrauma: Towards Personalized Markers
( MDPI , 2022 , Article Review)The proteome represents all the proteins expressed by a genome, a cell, a tissue, or an organism at any given time under defined physiological or pathological circumstances. Proteomic analysis has provided unparalleled ... -
Synthesis of New Chromene Derivatives Targeting Triple-Negative Breast Cancer Cells
( MDPI , 2023 , Article)Breast cancer continues to be the leading cause of cancer-related deaths among women worldwide. The most aggressive type of breast cancer is triple-negative breast cancer (TNBC). Indeed, not only does TNBC not respond well ... -
Retinoids and Reactive Oxygen Species in Cancer Cell Death and Therapeutics
( Springer Nature , 2022 , Book chapter)Retinoids are a large family of structurally related natural and synthetic molecules that exhibit a variety of effects in embryogenesis and adult life. The parent compound of retinoids is vitamin A which was first discovered ... -
Disease-Associated Regulation of Non-Coding RNAs by Resveratrol: Molecular Insights and Therapeutic Applications
( Frontiers Media S.A. , 2022 , Article Review)There have been significant advances, particularly over the last 20 years, in the identification of non-coding RNAs (ncRNAs) and their pathophysiological role in a wide range of disease states, particularly cancer and other ... -
Vascular inflammation: Players and modulators
( Bentham Science Publishers , 2021 , Article)- -
Cannabinoids and Myocardial Ischemia: Novel insights, Updated Mechanisms, and Implications for Myocardial Infarction
( Bentham Science Publishers , 2022 , Article)Cannabis is the most widely trafficked and abused illicit drug due to its calming psychoactive properties. It has been increasingly recognized as having potential health benefits and relatively less adverse health effects ... -
Identification of FAM173B as a protein methyltransferase promoting chronic pain
( Public Library of Science , 2018 , Article)Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic ... -
Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions [version 1; referees: 2 approved]
( F1000 Research Ltd , 2018 , Article)Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal ... -
A cephalometric morphometric study of age- and gender-dependent shape patterns of the sella turcica
(2018 , Article)The sella turcica is an important anatomic and radiologic entity. The shape of the sella turcica varies among normal individuals and can be influenced by local factors. The normal shape of sella turcica has been categorized ... -
Acute spontaneous spinal subdural hematoma: A case report
( International Scientific Information, Inc. , 2020 , Article)BACKGROUND: Spontaneous spinal subdural hematoma is a rare condition that can lead to devastating neurologic deficits, usually caused by coagulation abnormalities, trauma, underlying neoplasm, or arteriovenous malformation. ... -
Research on elastic recoil and restoration of vessel pulsatility of Zn-Cu biodegradable coronary stents
( De Gruyter , 2020 , Article)Coronary stents made of zinc (Zn)-0.8 copper (Cu) (in wt%) alloy were developed as biodegradable metal stents (Zn-Cu stents) in this study. The mechanical properties of the Zn-Cu stents and the possible gain effects were ... -
Letter to the editor: From Min Gong et al: "Risk for infections during treatment with denosumab for osteoporosis: a systematic review and meta-analysis"
( Endocrine Society , 2020 , Article)To the editor: We read with great interest the systematic review by Diker-Cohen et al (1) about the risk of infection under the treatment of denosumab for osteoporosis. This is a well-conducted systematic review that ... -
Pathophysiological Aspects of the Development of Abdominal Aortic Aneurysm with a Special Focus on Mitochondrial Dysfunction and Genetic Associations
( De Gruyter Open Ltd , 2021 , Article Review)Abdominal aortic aneurysm (AAA) is a complex degenerative vascular disease, with considerable morbidity and mortality rates among the elderly population. The mortality of AAA is related to aneurysm expansion (the enlargement ... -
Potential applicability of cytokines as biomarkers of disease activity in rheumatoid arthritis: Enzyme-linked immunosorbent spot assay-based evaluation of TNF-α, IL-1β, IL-10 and IL-17A
( Public Library of Science , 2021 , Article)Biomarkers play a pivotal role in the management of rheumatoid arthritis (RA) by facilitating early diagnosis and ‘treat to the target.’ However, no gold standard biomarker has been identified for monitoring the disease ... -
A program evaluation reporting student perceptions of early clinical exposure to primary care at a new medical college in Qatar
( BioMed Central Ltd , 2021 , Article)Background: Though common practice in Europe, few studies have described the efficacy of early clinical exposure (ECE) in the Middle East. The barriers to clinical learning experienced by these novice medical students have ...
