College of Medicine: Recent submissions
Now showing items 941-960 of 1731
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MicroRNA-mediated regulation of LDL receptor: biological and pharmacological implications.
( Europe PM , 2023 , Article)One of the main causes of atherosclerosis is a disruption in cellular cholesterol hemostasis. The low-density lipoprotein receptor (LDLR) is an important factor in maintaining cholesterol homeostasis by the receptor-mediated ... -
Applications of Artificial Intelligence in Philadelphia-Negative Myeloproliferative Neoplasms.
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Philadelphia-negative (Ph-) myeloproliferative neoplasms (MPNs) are a group of hematopoietic malignancies identified by clonal proliferation of blood cell lineages and encompasses polycythemia vera (PV), essential ... -
Role of E2F transcription factor in oral cancer: Recent insight and advancements
( Elsevier , 2023 , Article)The family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating the expression of several genes related to ... -
Epidemiology of herpes simplex virus type 2 in the Middle East and North Africa: Systematic review, meta-analyses, and meta-regressions
( Wiley-Blackwell , 2023 , Article)Herpes simplex virus type 2 (HSV-2) infection is a prevalent, sexually transmitted infection with poorly characterized prevalence in the Middle East and North Africa (MENA) region. This study characterized HSV-2 epidemiology ... -
How can we improve the measurement of receptor signaling bias?
( Taylor & Francis Group , 2023 , Article)G protein-coupled receptors (GPCRs) are flexible and dynamic signaling entities that can adopt multiple active conformations upon activation [Citation1,Citation2]. However, each agonist stabilizes a distinct receptor ... -
Applications of Artificial Intelligence in Thrombocytopenia
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Thrombocytopenia is a medical condition where blood platelet count drops very low. This drop in platelet count can be attributed to many causes including medication, sepsis, viral infections, and autoimmunity. Clinically, ... -
Corrigendum to “Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs” [Biochem. Pharmacol. 186 (2021) 114491]
( Elsevier , 2023 , Article)We regret to report that a mistake occurred in preparation of Fig. 4. The modified figure is included below. We apologize for any confusion this might have created. -
Autism and the Scaffolding Protein Neurobeachin
( Springer , 2022 , Book chapter)Autism is a group of early onsets, diverse, lifelong, neurodevelopmental conditions that affect social interaction, verbal and non-verbal communications as well as behavior. It is a multifactorial condition, which results ... -
Triple therapy with pravastatin, low molecular weight heparin and low dose aspirin improves placental haemodynamics and pregnancy outcomes in obstetric antiphospholipid syndrome in mice and women through a nitric oxide-dependent mechanism
( Elsevier , 2020 , Article)Objectives: A previous pilot study showed that pravastatin supplementation improved pregnancy outcomes in women with obstetric antiphospholipid syndrome (OAPS) that developed placental insufficiency despite standard of ... -
Modulation of preeclampsia by the cholinergic anti-inflammatory pathway: Therapeutic perspectives
( Elsevier , 2021 , Article Review)The cholinergic anti-inflammatory pathway (CAP) is vital for the orchestration of the immune and inflammatory responses under normal and challenged conditions. Over the past two decades, peripheral and central circuits of ... -
Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs
( Elsevier , 2021 , Article)Diabetic nephropathy is a major health challenge with considerable economic burden and significant impact on patients’ quality of life. Despite recent advances in diabetic patient care, current clinical practice guidelines ... -
Acupuncture vs Noninsertive Sham Acupuncture in Aging Patients with Degenerative Lumbar Spinal Stenosis: A Randomized Controlled Trial
( Elsevier , 2020 , Article)Background: Acupuncture is commonly used to treat degenerative lumbar spinal stenosis in Asian countries. However, rigorous data regarding the efficacy and safety of acupuncture for aging patients are currently lacking. ... -
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
( Elsevier , 2022 , Article)A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ... -
RKIP in human diseases and its potential as a prognostic indicator and therapeutic target
( Elsevier , 2020 , Book chapter)The Raf kinase inhibitory protein (RKIP) is an inhibitor of the RAF/MEK/ERK and NF-κB signaling pathways, through which it regulates several key processes of the cell's physiology, such as its proliferation, motility and ... -
Tumor-Type Agnostic, Targeted Therapies: BRAF Inhibitors Join the Group
( Academy of Sciences and Arts of Bosnia and Herzegovina , 2022 , Article)In the present review, we briefly discuss the breakthrough advances in precision medicine using a tumor-agnostic approach and focus on BRAF treatment modalities, the mechanisms of resistance and the diagnostic approach in ... -
ApoM binds endotoxin contributing to neutralization and clearance by High Density Lipoprotein.
( Elsevier , 2023 , Article)HDL possesses anti-inflammatory properties, however, the exact mechanism is not fully understood. Endotoxin is a potent inducers of TLR4 signaling, leading to inflammatory mediators' release. It has been estimated that ... -
Pathogenicity and virulence of monkeypox at the human-animal-ecology interface
( Taylor & Francis , 2023 , Article)Monkeypox (Mpox) was mostly limited to Central and Western Africa, but recently it has been reported globally. The current review presents an update on the virus, including ecology and evolution, possible drivers of ... -
Pathogenicity and virulence of monkeypox at the human-animal-ecology interface.
( Taylor & Francis Group. , 2023 , Article)Monkeypox (Mpox) was mostly limited to Central and Western Africa, but recently it has been reported globally. The current review presents an update on the virus, including ecology and evolution, possible drivers of ... -
Literature as a Pedagogical Tool in Medical Education: The Silent Patient Case
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)The arts have seen increasing use in medical education over the last 4 decades. Literature in particular is now frequently used as an educational tool in different medical humanities programmes. This paper analyses Alex ... -
Antibiotic prescriptions for oral diseases in India: evidence from national prescription data
( Springer Nature , 2023 , Article)Introduction: The key objective of this research was to describe the prescription rate of various antibiotics for dental problems in India and to study the relevance of the prescriptions by analysing antibiotic types ...
