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AuthorAhmed, Safwat A.
AuthorMesbah, Mostafa K.
AuthorYoussef, Diaa T.
AuthorKhalifa, Sherief I.
Available date2016-03-09T14:00:55Z
Publication Date2014-01
Publication NameNatural Product Research
CitationAhmed, S.A., Mesbah, M.K., Youssef, D.T., Khalifa, S.I. "Microbial production of 1α-hydroxyvitamin D3 from vitamin D3" (2014) Natural Product Research, 28 (7), pp. 444-448.
AbstractThe microbial transformation of vitamin D3 (1) by the fungi Candida maltosa R42 and Botrytis allii NRRL 2502 was investigated. Incubation of compound 1 with C. maltosa R42 and B. allii NRRL 2502 produced the same three more polar metabolites in small yields. The main metabolite was identified as 1α-hydroxyvitamin D3 (2). This biotransformation has utility as a possible tool for the production of 1α-hydroxyvitamin D3 from the readily available vitamin D3 for patients with compromised kidney function.
PublisherTaylor and Francis Ltd.
SubjectBotrytis allii NRRL 2502
SubjectCandida maltosa R42
SubjectRenal failure
TitleMicrobial production of 1α-hydroxyvitamin D3 from vitamin D3
Issue Number7
Volume Number28

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