تصفح College of Pharmacy حسب المؤلف "Prabhu, Kirti S."
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Exploring the in vivo anti-cancer potential of Neosetophomone B in leukemic cells using a zebrafish xenograft model
Kuttikrishnan, Shilpa; Hasan, Maram; Prabhu, Kirti S.; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Alali, Feras Q.; Ahmad, Aamir; Pourkarimi, Ehsan; Bhat, Ajaz A.; Yalcin, Huseyin C.; Uddin, Shahab... more authors ... less authors ( Elsevier Inc. , 2024 , Article)Neosetophomone B (NSP–B) is a unique meroterpenoid fungal secondary metabolite that has previously demonstrated promising anti-cancer properties against various cancer cell lines in vitro. However, its in vivo anti-cancer ... -
Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway
Akhtar, Sabah; Zarif, Lubna; Kuttikrishnan, Shilpa; Prabhu, Kirti S.; Patil, Kalyani; Nisar, Sabah; Abou-Saleh, Haissam; Merhi, Maysaloun; Dermime, Said; Bhat, Ajaz A.; Uddin, Shahab... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Multiple myeloma (MM) is a hematological disorder characterized by the abnormal expansion of plasma cells in the bone marrow. Despite great advances over the past three decades in discovering the efficacious therapies for ... -
Natural resorcylic acid lactones: A chemical biology approach for anticancer activity
Shilpa, Kuttikrishnan; Prabhu, Kirti S.; Al Sharie, Ahmed H.; Al Zu'bi, Yazan O.; Alali, Feras Q.; Oberlies, Nicholas H.; Ahmad, Aamir; El-Elimat, Tamam; Uddin, Shahab... more authors ... less authors ( Elsevier , 2022 , Article)Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a broad range of biological activities, including ... -
Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway
Kuttikrishnan, Shilpa; Ahmad, Fareed; Mateo, Jericha M.; Prabhu, Kirti S.; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Akil, Ammira S.Alshabeeb; Bhat, Ajaz A.; Alali, Feras Q.; Uddin, Shahab... more authors ... less authors ( Wiley-Blackwell , 2023 , Article)Multiple myeloma (MM) is a hematologic malignancy associated with malignant plasma cell proliferation in the bone marrow. Despite the available treatments, drug resistance and adverse side effects pose significant challenges, ... -
Thiostrepton inhibits growth and induces apoptosis by targeting FoxM1/SKP2/MTH1 axis in B-precursor acute lymphoblastic leukemia cells
Kuttikrishnan, Shilpa; Prabhu, Kirti S.; Khan, Abdul Q.; Alali, Feras Q.; Ahmad, Aamir; Uddin, Shahab... more authors ... less authors ( Taylor and Francis Group , 2021 , Article)Forkhead box M1 (FoxM1) is a transcription factor that plays an important role in the etiology of many cancers, however, its role has not been elucidated in B-precursor acute lymphoblastic leukemia (B-pre-ALL). In the ...