تصفح College of Pharmacy حسب المؤلف "n 2011066353"
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The effect of novel nitrogen-based chalcone analogs on colorectal cancer cells: Insight into the molecular pathways
Arij Fouzat, Hassan; Hussein, Ola; Al-Barazenji, Tara; Allouch, Asma; Kamareddine, Layla; Malki, Ahmed; Moustafa, Ala‐Eddin Al; Khalil, Ashraf... more authors ... less authors ( Elsevier , 2024 , Article)In colorectal cancer (CRC), aberrations in KRAS are associated with aggressive tumorigenesis and an overall low survival rate because of chemoresistance and adverse effects. Ergo, complementary, and integrative medicines ... -
Effect of Water-Pipe Smoking on the Normal Development of Zebrafish
Zakaria, Zain Zaki; Aladwi, Shaima Ahmad; Benslimane, Fatiha; Al-Absi, Enas S.; Al-Shafai, Mashael; Yalcin, Huseyin C.; Khalil, Ashraf; Al Moustafa, Ala-Eddin; Al-Asmakh, Maha... more authors ... less authors ( MDPI , 2021 , Article)Background: Among all types of tobacco consumption,Water-Pipe Smoking (WPS) is the most widely used in the Middle East and second-most in several other countries. The effect of WPS on normal development is not yet fully ... -
Structure-activity relationship investigation of methoxy substitution on anticancer pyrimido[4,5-c]quinolin-1(2H)-ones
Metwally, Kamel; Khalil, Ashraf; Sallam, Asmaa; Pratsinis, Harris; Kletsas, Dimitris; El Sayed, Khalid... more authors ... less authors (2013 , Article)Pyrimido[4,5-c]quinolin-1(2H)-one derivatives were shown to exert interesting biological activities including anticancer, antimicrobial, and cardiovascular. Substitution with methoxy groups played a crucial role in the ... -
Structure–activity relationship of piperine and its synthetic amide analogs for therapeutic potential to prevent experimentally induced ER stress in vitro
Hammad, Ayat S.; Ravindran, Sreenithya; Khalil, Ashraf; Munusamy, Shankar ( Springer Netherlands , 2017 , Article)Endoplasmic reticulum (ER) is the key organelle involved in protein folding and maturation. Emerging studies implicate the role of ER stress in the development of chronic kidney disease. Thus, there is an urgent need for ...