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    Effect of Water-Pipe Smoking on the Normal Development of Zebrafish

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    2021-HCYalcin-IJERPH-water pipe-zebrafish.pdf (3.214Mb)
    Date
    2021-11-06
    Author
    Zakaria, Zain Zaki
    Aladwi, Shaima Ahmad
    Benslimane, Fatiha
    Al-Absi, Enas S.
    Al-Shafai, Mashael
    Yalcin, Huseyin C.
    Khalil, Ashraf
    Al Moustafa, Ala-Eddin
    Al-Asmakh, Maha
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    Abstract
    Background: Among all types of tobacco consumption,Water-Pipe Smoking (WPS) is the most widely used in the Middle East and second-most in several other countries. The effect of WPS on normal development is not yet fully understood, thus the aim of this study is to explore the acute toxicity effects of WPS extract on zebrafish larvae. Methods: In this study, we compared the effects of WPS smoke condensates at concentrations varying from 50 to 200 g/mL on developmental, cardiac, and behavioural (neurotoxicity) functions. Gene expression patterns of cardiac biomarkers were also evaluated by RT-qPCR. Results: Exposing zebrafish embryos to 50, 100, 150 and 200 g/mL WPS for three days did not affect the normal morphology of Zebrafish embryos, as the tail flicking, behavioural and locomotion assays did not show any change. However, WPS deregulated cardiac markers including atrial natriuretic peptide (ANP/NPPA) and brain natriuretic peptide (BNP/NPPB). Furthermore, it induced apoptosis in a dose-dependent manner. Conclusion: Our data demonstrate that WPS can significantly affect specific cardiac parameters during the normal development of zebrafish. Further investigations are necessary to elucidate the pathogenic outcome of WPS on different aspects of human life, including pregnancy.
    DOI/handle
    http://dx.doi.org/10.3390/ijerph182111659
    http://hdl.handle.net/10576/24860
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