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Metformin Attenuates Albumin-induced Alterations in Renal Tubular Cells In Vitro
(
Wiley Periodicals, Inc
, 2017 , Article)
Proteinuria (albuminuria) plays a crucial role in the etiology of chronic kidney disease (CKD) via alteration of multiple signaling pathways and cellular process in renal cells. The objectives of this study are to investigate ...
How ethics influence intentions to buy counterfeit drugs: perceptions of policymakers, community pharmacists and consumers in Sudan
(
John Wiley & Sons, Ltd.
, 2014 , Article)
Objectives
The ethical attitudes of consumers have been widely explored in the literature as a key factor influencing the purchase of counterfeit products. However, the manner in which consumers make decisions regarding ...
Effect of hyperlipidemia on ketoconazole-midazolam drug-drug interaction in rat
(
John Wiley & Sons, Ltd.
, 2011 , Article)
Hyperlipidemia (HL) was previously shown to lower liver uptake of the more potent (-) enantiomer of ketoconazole (KTZ) in rat. The current study examined the possible modifying influence of experimental HL on a KTZ ...
Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes
(
Wiley Periodicals, Inc.
, 2013 , Article)
Hyperlipidemia can significantly increase amiodarone (AM) in vivo liver uptake and decrease its velocity of microsomal metabolism. Here, hepatocytes isolated from normolipidemic (NL) and hyperlipidemic rats were incubated ...
Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes
(
John Wiley & Sons, Ltd
, 2012 , Article)
Experimental hyperlipidemia has shown to decrease cytochrome P450 3A4 and 2C11 expression and to increase liver concentrations and the plasma protein binding of halofantrine (HF) enantiomers. The present study examined the ...
Impact of the CYP4F2 p.V433M Polymorphism on Coumarin Dose Requirement: Systematic Review and Meta-Analysis
(
Nature Publishing Group
, 2012 , Article)
A systematic review and a meta-analysis were performed to quantify the accumulated information from genetic association studies investigating the impact of the CYP4F2 rs2108622 (p.V433M) polymorphism on coumarin dose ...
Cytotoxic Homoisoflavones from the Bulbs of Bellevalia eigii
(
American Chemical Society
, 2015 , Article)
Eight new and 10 known compounds were isolated from an organic extract of the bulbs of Bellevalia eigii as part of a search for anticancer leads from native plants of Jordan. Of these, the series of 16 homoisoflavonoids ...
Assessing the effectiveness of a pharmacist-delivered smoking cessation program in the State of Qatar: study protocol for a randomized controlled trial
(
BioMed Central
, 2015 , Article)
Background:
It had been reported that up to 37% of the adult male population smokes cigarettes in Qatar. The
Global Youth Tobacco Survey also stated that 13.4% of male school students aged 13 to 15 years in Qatar smoke ...
An inventory of diabetes care in Qatar
(
John Wiley & Sons, Ltd.
, 2011 , Article)
Diabetes is a global epidemic and the highest prevalence rates in the world are found in Gulf Corporation Council countries, including Qatar. The country's Supreme Council of Health has recognised its significant health ...
A survey on the awareness and attitude of pharmacists and doctors towards the application of pharmacogenomics and its challenges in Qatar
(
John Wiley & Sons, Ltd.
, 2015 , Article)
RATIONALE, AIMS AND OBJECTIVES:
Pharmacists are expected to play an important role in applying pharmacogenomics discoveries to patient care. Despite the increased attention to genetic research in Qatar, clinicians' attitudes ...