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Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium
(
Wiley
, 2020 , Article)
Selenium is an essential trace element important for human health. A balanced intake is, however, crucial to maximize the health benefits of selenium. At physiological concentrations, selenium mediates antioxidant, ...
A cross-sectional survey of the perspectives of older people in the Scottish Highlands on the management of their chronic pain.
(
Oxford University Press
, 2020 , Article)
Although there is evidence of suboptimal outcomes in older people with chronic pain, little emphasis has been placed on those in remote and rural settings. To describe the perspectives of older people in the Scottish ...
Economic Evaluations of CYP2C19 Genotype-Guided Antiplatelet Therapy Compared to the Universal Use of Antiplatelets in Patients With Acute Coronary Syndrome: A Systematic Review.
(
SAGE Publications
, 2020 , Article)
Clopidogrel is widely used after the percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) and requires activation by cytochrome P450 (CYP), primarily CYP2C19. Patients with CYP2C19 ...
EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: and Rat Studies.
(
American Chemical Society
, 2020 , Article)
Gefitinib (GEF) is a selective inhibitor of the epidermal growth factor receptor (EGFR) used to treat non-small cell lung cancer. Yet, few cases of cardiotoxicity have been reported. However, the role of the PTEN/Akt/FoxO3a ...
Implementation models: applicability across research, implementation, culture and context
(
University of Adelaide, Joanna Briggs Institute
, 2020 , Article)
The Joanna Briggs Institute (JBI) Model for Evidencebased
Healthcare is a whole-of-health model that brings
together healthcare needs, research generation, synthesis,
transfer and implementation while accounting ...
Pharmacists providing prescribing advice and education to healthcare professionals in community, primary care and outpatient settings (Protocol)
(
Wiley
, 2020 , Article)
Objectives
This is a protocol for a Cochrane Review (intervention). The objectives are as follows:
Main objective
To assess the eHect of pharmacists’ prescribing advice, compared to usual care or other forms of ...
Naked Poly(amidoamine) Dendrimer Nanoparticles Exhibit Intrinsic Embryotoxicity During the Early Stages of Normal Development.
(
American Science Publishers ASP
, 2020 , Article)
To investigate the impact of poly(amidoamine) dendrimers (PAMAMs) in the embryo, we explored the outcome of different generations (G₄ and G) on the early stages of embryogenesis using the chicken embryo as a model. We also ...
Crosstalk between HER2 and PD-1/PD-L1 in Breast Cancer: From Clinical Applications to Mathematical Models.
(
Springer
, 2020 , Article)
Breast cancer is one of the major causes of mortality in women worldwide. The most aggressive breast cancer subtypes are human epidermal growth factor receptor-positive (HER2) and triple-negative breast cancers. Therapies ...
Health-related stakeholders’ perceptions of clinical pharmacy services in Qatar
(
Springer
, 2020 , Article)
© 2020, The Author(s). Background In Qatar, the National Vision 2030 and the National Health Strategy 2018–2022 articulate the need to improve healthcare delivery by better utilisation of the skilled workforce. In this ...
Global comparison of professional positioning by pharmacy programs towards prospective students
(
Elsevier
, 2020 , Article)
© 2020 Elsevier Inc. Background: Enrolment of capable prospective students for pharmacy programs is a major priority for the profession. The way in which these students perceive a future career in pharmacy may be dependent ...