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EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: and Rat Studies.
(
American Chemical Society
, 2020 , Article)
Gefitinib (GEF) is a selective inhibitor of the epidermal growth factor receptor (EGFR) used to treat non-small cell lung cancer. Yet, few cases of cardiotoxicity have been reported. However, the role of the PTEN/Akt/FoxO3a ...
The effect of genetic and nongenetic factors on warfarin dose variability in Qatari population.
(
Pharmacogenomics Journal
, 2020 , Article)
The objective of this study is to estimate the prevalence of VKORC1, CYP2C9, and CYP4F2 genetic variants and their contribution to warfarin dose variability in Qataris. One hundred and fifty warfarin-treated Qatari patients ...
Examining the disconnect between communities of practice learning theory and educational practices in the pharmd program in qatar
(
American Association of Colleges of Pharmacy
, 2020 , Article)
Objective. To examine the Qatar University Doctor of Pharmacy (PharmD) program for evidence of incorporation of communities of practice (CoP) learning theory. Methods. A developed CoP framework was used as a theoretical ...
Implementation models: applicability across research, implementation, culture and context
(
University of Adelaide, Joanna Briggs Institute
, 2020 , Article)
The Joanna Briggs Institute (JBI) Model for Evidencebased
Healthcare is a whole-of-health model that brings
together healthcare needs, research generation, synthesis,
transfer and implementation while accounting ...
Comprehensive medication reviews by ward-based pharmacists in Swedish hospitals: What does the patient have to say?
(
Wiley
, 2020 , Article)
Inappropriate medication prescribing and use amongst older patients is a major patient safety and health care problem. To promote appropriate medication prescribing and use, comprehensive medication reviews (CMRs) by ...
Knowledge and Attitudes on Khat Use among Yemeni Health Sciences Students
(
Taylor and Francis Ltd
, 2020 , Article)
Background: Khat chewing has a negative impact on an individual’s life. Objectives: The study was execute to assess health sciences students’ knowledge and attitudes regarding khat use in Yemen. Methods: This survey involved ...
Evaluating prescribing competencies covered in a Canadian-accredited undergraduate pharmacy program in Qatar: A curriculum mapping process
(
BioMed Central Ltd
, 2020 , Article)
Background: The objective of this study was to evaluate the existing Bachelor of Science in Pharmacy [BSc (Pharm)] curriculum at Qatar University College of Pharmacy (QU CPH), for addressing international prescribing ...
Anti-hypertrophic effect of Na+/H+ exchanger-1 inhibition is mediated by reduced cathepsin B
(
Elsevier
, 2020 , Article)
Previous studies have established the role of Na+/H+ exchanger isoform-1 (NHE1) and cathepsin B (Cat B) in the development of cardiomyocyte hypertrophy (CH). Both NHE1 and Cat B are activated under acidic conditions ...
Assessment of the attitude, awareness and practice of periprocedural warfarin management among health care professional in Qatar. A cross sectional survey
(
Springer
, 2020 , Article)
It is estimated that 10–15% of oral anticoagulant (OAC) patients, would need to hold their OAC for scheduled surgery. Especially for warfarin, this process is complex and requires multi-layer risk assessment and decisions ...
Crosstalk between HER2 and PD-1/PD-L1 in Breast Cancer: From Clinical Applications to Mathematical Models.
(
Springer
, 2020 , Article)
Breast cancer is one of the major causes of mortality in women worldwide. The most aggressive breast cancer subtypes are human epidermal growth factor receptor-positive (HER2) and triple-negative breast cancers. Therapies ...