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A cross-sectional survey of the perspectives of older people in the Scottish Highlands on the management of their chronic pain.
(
Oxford University Press
, 2020 , Article)
Although there is evidence of suboptimal outcomes in older people with chronic pain, little emphasis has been placed on those in remote and rural settings. To describe the perspectives of older people in the Scottish ...
Economic Evaluations of CYP2C19 Genotype-Guided Antiplatelet Therapy Compared to the Universal Use of Antiplatelets in Patients With Acute Coronary Syndrome: A Systematic Review.
(
SAGE Publications
, 2020 , Article)
Clopidogrel is widely used after the percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) and requires activation by cytochrome P450 (CYP), primarily CYP2C19. Patients with CYP2C19 ...
EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: and Rat Studies.
(
American Chemical Society
, 2020 , Article)
Gefitinib (GEF) is a selective inhibitor of the epidermal growth factor receptor (EGFR) used to treat non-small cell lung cancer. Yet, few cases of cardiotoxicity have been reported. However, the role of the PTEN/Akt/FoxO3a ...
Implementation models: applicability across research, implementation, culture and context
(
University of Adelaide, Joanna Briggs Institute
, 2020 , Article)
The Joanna Briggs Institute (JBI) Model for Evidencebased
Healthcare is a whole-of-health model that brings
together healthcare needs, research generation, synthesis,
transfer and implementation while accounting ...
Pharmacists providing prescribing advice and education to healthcare professionals in community, primary care and outpatient settings (Protocol)
(
Wiley
, 2020 , Article)
Objectives
This is a protocol for a Cochrane Review (intervention). The objectives are as follows:
Main objective
To assess the eHect of pharmacists’ prescribing advice, compared to usual care or other forms of ...
Naked Poly(amidoamine) Dendrimer Nanoparticles Exhibit Intrinsic Embryotoxicity During the Early Stages of Normal Development.
(
American Science Publishers ASP
, 2020 , Article)
To investigate the impact of poly(amidoamine) dendrimers (PAMAMs) in the embryo, we explored the outcome of different generations (G₄ and G) on the early stages of embryogenesis using the chicken embryo as a model. We also ...
A rapid review and narrative synthesis of hospital to community pharmacy transfer of care services in england
(
Wiley
, 2020 , Article)
Objectives A new discharge medicines service in England has been proposed for rollout in July
2020. This study aims to appraise the evidence for hospital to community pharmacy referral services
in England. A rapid review ...
Suppression of GATA-3 increases adipogenesis, reduces inflammation and improves insulin sensitivity in 3T3L-1 preadipocytes
(
Elsevier
, 2020 , Article)
© 2020 Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes. Adipose tissue inflammation is a crucial mediator of this process. GATA-3 plays important ...
Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells
(
Wiley
, 2020 , Article)
© 2020 Royal Pharmaceutical Society Aim: Cisplatin is a standard treatment approach against lung adenocarcinoma. Resistance to cisplatin and the toxic side effects of cisplatin continue to remain a challenge. Combining ...
Exploring the experiences and preparedness of humanitarian pharmacists in responding to an emergency-response situation
(
Elsevier
, 2020 , Article)
Background: Pharmacists are more frequently being deployed along with other members of the multi-disciplinary team in order to provide humanitarian aid. This team will need to work collaboratively to overcome challenges ...