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المؤلفMukherjee, Anirban Goutam
المؤلفWanjari, Uddesh Ramesh
المؤلفKannampuzha, Sandra
المؤلفMurali, Reshma
المؤلفNamachivayam, Arunraj
المؤلفGanesan, Raja
المؤلفDey, Abhijit
المؤلفBabu, Achsha
المؤلفRenu, Kaviyarasi
المؤلفVellingiri, Balachandar
المؤلفRamanathan, Gnanasambandan
المؤلفGeorge Priya Doss, C.
المؤلفElsherbiny, Nehal
المؤلفElsherbini, Amira M.
المؤلفAlsamman, Alsamman M.
المؤلفZayed, Hatem
المؤلفGopalakrishnan, Abilash Valsala
تاريخ الإتاحة2023-05-24T11:21:40Z
تاريخ النشر2023-01-14
اسم المنشورMetabolites
المعرّفhttp://dx.doi.org/10.3390/metabo13010129
الاقتباسMukherjee, A. G., Wanjari, U. R., Kannampuzha, S., Murali, R., Namachivayam, A., Ganesan, R., ... & Gopalakrishnan, A. V. (2023). The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review. Metabolites, 13(1), 129.
الرقم المعياري الدولي للكتاب2218-1989
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85146838178&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/43444
الملخصAs a complex endocrine and metabolic condition, polycystic ovarian syndrome (PCOS) affects women’s reproductive health. These common symptoms include hirsutism, hyperandrogenism, ovulatory dysfunction, irregular menstruation, and infertility. No one knows what causes it or how to stop it yet. Alterations in gut microbiota composition and disruptions in secondary bile acid production appear to play a causative role in developing PCOS. PCOS pathophysiology and phenotypes are tightly related to both enteric and vaginal bacteria. Patients with PCOS exhibit changed microbiome compositions and decreased microbial diversity. Intestinal microorganisms also alter PCOS patient phenotypes by upregulating or downregulating hormone release, gut-brain mediators, and metabolite synthesis. The human body’s gut microbiota, also known as the “second genome,” can interact with the environment to improve metabolic and immunological function. Inflammation is connected to PCOS and may be caused by dysbiosis in the gut microbiome. This review sheds light on the recently discovered connections between gut microbiota and insulin resistance (IR) and the potential mechanisms of PCOS. This study also describes metabolomic studies to obtain a clear view of PCOS and ways to tackle it.
اللغةen
الناشرMultidisciplinary Digital Publishing Institute (MDPI)
الموضوعmetabolomics
metagenomics
microbiome
PCOS
therapy
العنوانThe Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review
النوعArticle
رقم العدد1
رقم المجلد13
dc.accessType Open Access


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