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AuthorShouk, Reem
AuthorAbdou, Aya
AuthorShetty, Kalidas
AuthorSarkar, Dipayan
AuthorEid, Ali H.
Available date2016-04-18T08:10:04Z
Publication Date2014-02
Publication NameNutrition Research
CitationShouk, R., Abdou, A., Shetty, K., Sarkar, D., Eid, A.H. "Mechanisms underlying the antihypertensive effects of garlic bioactives" (2014) Nutrition Research, 34 (2), pp. 106-115.
AbstractCardiovascular disease remains the leading cause of death worldwide with hypertension being a major contributing factor to cardiovascular disease-associated mortality. On a population level, non-pharmacological approaches, such as alternative/complementary medicine, including phytochemicals, have the potential to ameliorate cardiovascular risk factors, including high blood pressure. Several epidemiological studies suggest an antihypertensive effect of garlic (Allium sativum) and of many its bioactive components. The aim of this review is to present an in-depth discussion regarding the molecular, biochemical and cellular rationale underlying the antihypertensive properties of garlic and its bioactive constituents with a primary focus on S-allyl cysteine and allicin. Key studies, largely from PubMed, were selected and screened to develop a comprehensive understanding of the specific role of garlic and its bioactive constituents in the management of hypertension. We also reviewed recent advances focusing on the role of garlic bioactives, S-allyl cysteine and allicin, in modulating various parameters implicated in the pathogenesis of hypertension. These parameters include oxidative stress, nitric oxide bioavailability, hydrogen sulfide production, angiotensin converting enzyme activity, expression of nuclear factor- ?B and the proliferation of vascular smooth muscle cells. This review suggests that garlic and garlic derived bioactives have significant medicinal properties with the potential for ameliorating hypertension and associated morbidity; however, further clinical and epidemiological studies are required to determine completely the specific physiological and biochemical mechanisms involved in disease prevention and management.
Sponsorgrant # NPRP 4-571-3-171 from the Qatar National Research Fund (a member of Qatar Foundation).
PublisherElsevier Inc.
SubjectAllium sativum
SubjectS-Allyl cysteine
SubjectAngiotensin-converting enzyme
SubjectCardiovascular disease
SubjectDiastolic blood pressure
SubjectSystolic blood pressure
SubjectVascular smooth muscle cell
TitleMechanisms underlying the antihypertensive effects of garlic bioactives
Issue Number2
Volume Number34

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