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AuthorHabchi, Christie
AuthorBadran, Adnan
AuthorSrour, Mortada
AuthorDaou, Anis
AuthorBaydoun, Elias
AuthorHamade, Kamar
AuthorHijazi, Akram
Available date2023-06-21T07:06:51Z
Publication Date2023-04-05
Publication NameProcesses
Identifierhttp://dx.doi.org/10.3390/pr11041111
CitationHabchi, C., Badran, A., Srour, M., Daou, A., Baydoun, E., Hamade, K., & Hijazi, A. (2023). Determination of the Antioxidant and Antiproliferative Properties of Pomegranate Peel Extract Obtained by Ultrasound on HCT-116 Colorectal Cancer Cell Line. Processes, 11(4), 1111.
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85156176651&origin=inward
URIhttp://hdl.handle.net/10576/44639
AbstractColorectal cancer (CRC) is one of the most common cancers in the world. When treating patients, therapeutic agents have side effects; hence, the use of natural compounds found in medicinal plants including pomegranate. Ultrasound assisted extraction (UAE) is a new technique evolving to the detriment of traditional methods such as maceration. In this study, we investigated the antioxidant and anticancer effect of pomegranate peel extracts obtained by maceration and UAE at three different ultrasonic power levels (P1 = 10 W; P2 = 50 W; P3 = 100 W) on HCT-116 colorectal cancer cells. Phytochemical screening highlighted the presence of primary and secondary metabolites in pomegranate peels. In addition, the ethanolic extract obtained by UAE at 50 W was shown to be the most concentrated in phenolic and flavonoid compounds and have the most powerful antioxidant activity, which reached a maximum activity of 92% as determined by DPPH test. Similarly, the MTT cell viability test showed that the extract obtained by UAE at 50 W had the most potent inhibitory effect compared to the other extracts. In conclusion, the UAE at 50 W was shown to be the most suitable and efficient extraction technique to obtain bioactive compounds from pomegranate peel extracts that can be used in the treatment of CRC.
SponsorThis research was funded by Anis Daou, Adnan Badran, and the Lebanese University.
Languageen
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
Subjectantioxidant
antiproliferative
colorectal cancer
maceration
pomegranate
ultrasound assisted extraction
TitleDetermination of the Antioxidant and Antiproliferative Properties of Pomegranate Peel Extract Obtained by Ultrasound on HCT-116 Colorectal Cancer Cell Line
TypeArticle
Issue Number4
Volume Number11
ESSN2227-9717
dc.accessType Open Access


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