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المؤلفLubna, Therachiyil
المؤلفHussein, Ola J.
المؤلفUddin, Shahab
المؤلفKorashy, Hesham M.
تاريخ الإتاحة2023-06-22T05:40:47Z
تاريخ النشر2022-11-30
اسم المنشورSeminars in Cancer Biology
المعرّفhttp://dx.doi.org/10.1016/j.semcancer.2022.10.003
الرقم المعياري الدولي للكتاب1044579X
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S1044579X22002073
معرّف المصادر الموحدhttp://hdl.handle.net/10576/44676
الملخصGynecological malignancies are a female type of cancers that affects the reproductive system. Cancer metastasis or recurrence mediated by cellular invasiveness occurs at advanced stages of cancer progression. Cancer Stem Cells (CSCs) enrichment in tumors leads to chemoresistance, which results in cancer mortality. Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons is associated with an increased the risk of CSC enrichment in gynecological cancers. One of the important pathways that mediates the metabolism and bioactivation of these environmental chemicals is the transcription factor, aryl hydrocarbon receptor (AhR). The present review explores the molecular mechanisms regulating the crosstalk and interaction of the AhR with cancer-related signaling pathways, such as apoptosis, epithelial-mesenchymal transition, immune checkpoints, and G-protein-coupled receptors in several gynecological malignancies such as ovarian, uterine, endometrial, and cervical cancers. The review also discusses the potential of targeting the AhR pathway as a novel chemotherapy for gynecological cancers.
راعي المشروعThis publication was supported by Qatar University Internal Grant No. IRCC-2022-484 and Hamad medical Corporation, Medical Research Center Grant No. MRC-01-21-820, Doha, Qatar. Open Access funding is provided by the Qatar National Library.
اللغةen
الناشرElsevier
الموضوعAryl hydrocarbon receptor
CYP1A1/ CYP1B1
Chemoresistance
Gynecological cancers
Stemness markers
Cancer stem cells
العنوانRegulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathways
النوعArticle Review
الصفحات1186-1202
رقم المجلد86
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Open Access


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