Show simple item record

AuthorLubna, Therachiyil
AuthorHussein, Ola J.
AuthorUddin, Shahab
AuthorKorashy, Hesham M.
Available date2023-06-22T05:40:47Z
Publication Date2022-11-30
Publication NameSeminars in Cancer Biology
Identifierhttp://dx.doi.org/10.1016/j.semcancer.2022.10.003
ISSN1044579X
URIhttps://www.sciencedirect.com/science/article/pii/S1044579X22002073
URIhttp://hdl.handle.net/10576/44676
AbstractGynecological malignancies are a female type of cancers that affects the reproductive system. Cancer metastasis or recurrence mediated by cellular invasiveness occurs at advanced stages of cancer progression. Cancer Stem Cells (CSCs) enrichment in tumors leads to chemoresistance, which results in cancer mortality. Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons is associated with an increased the risk of CSC enrichment in gynecological cancers. One of the important pathways that mediates the metabolism and bioactivation of these environmental chemicals is the transcription factor, aryl hydrocarbon receptor (AhR). The present review explores the molecular mechanisms regulating the crosstalk and interaction of the AhR with cancer-related signaling pathways, such as apoptosis, epithelial-mesenchymal transition, immune checkpoints, and G-protein-coupled receptors in several gynecological malignancies such as ovarian, uterine, endometrial, and cervical cancers. The review also discusses the potential of targeting the AhR pathway as a novel chemotherapy for gynecological cancers.
SponsorThis publication was supported by Qatar University Internal Grant No. IRCC-2022-484 and Hamad medical Corporation, Medical Research Center Grant No. MRC-01-21-820, Doha, Qatar. Open Access funding is provided by the Qatar National Library.
Languageen
PublisherElsevier
SubjectAryl hydrocarbon receptor
CYP1A1/ CYP1B1
Chemoresistance
Gynecological cancers
Stemness markers
Cancer stem cells
TitleRegulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathways
TypeArticle Review
Pagination1186-1202
Volume Number86
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record