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AuthorBernardo-Menezes, Lucas Coêlho
AuthorAgrelli, Almerinda
Authorde Oliveira, Ana Sofia Lima Estevão
Authorde Moura, Ronald Rodrigues
AuthorCrovella, Sergio
AuthorBrandão, Lucas André Cavalcanti
Available date2023-06-22T09:09:07Z
Publication Date2022-01-01
Publication NameRevista da Sociedade Brasileira de Medicina Tropical
Identifierhttp://dx.doi.org/10.1590/0037-8682-0263-2022
CitationBernardo-Menezes, L. C., Agrelli, A., Oliveira, A. S. L. E., Moura, R. R., Crovella, S., & Brandão, L. A. C. (2022). An overview of Zika virus genotypes and their infectivity. Revista da Sociedade Brasileira de Medicina Tropical, 55, e02632022. https://doi.org/10.1590/0037-8682-0263-2022
ISSN00378682
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85139365987&origin=inward
URIhttp://hdl.handle.net/10576/44681
AbstractZika virus (ZIKV) is an enveloped, single-stranded RNA arbovirus belonging to the genus Flavivirus. It was first isolated from a sentinel monkey in Uganda in 1947. More recently, ZIKV has undergone rapid geographic expansion and has been responsible for outbreaks in Southeast Asia, the Pacific Islands, and America. In this review, we have highlighted the influence of viral genetic variants on ZIKV pathogenesis. Two major ZIKV genotypes (African and Asian) have been identified. The Asian genotype is subdivided into Southwest Asia, Pacific Island, and American strains, and is responsible for most outbreaks. Non-synonymous mutations in ZIKV proteins C, prM, E, NS1, NS2A, NS2B, NS3, and NS4B were found to have a higher prevalence and association with virulent strains of the Asian genotype. Consequently, the Asian genotype appears to have acquired higher cellular permissiveness, tissue persistence, and viral tropism in human neural cells. Therefore, mutations in specific coding regions of the Asian genotype may enhance ZIKV infectivity. Considering that mutations in the genomes of emerging viruses may lead to new virulent variants in humans, there is a potential for the re-emergence of new ZIKV cases in the future.
SponsorThis study was financed by the National Council for the Improvement of Higher Education – Brazil (CAPES) – Finance Code 001, National Council for Scientific and Technological Development – Brazil (CNPq) and the Department of Science and Technology of the Ministry of Health – Brazil (Decit/SCTIE/MS).
Languageen
PublisherSociedade Brasileira de Medicina Tropical
SubjectBrazilian isolate
Congenital Zika syndrome
Mammalian cells
Sexual transmission route
Viral reservoir
TitleAn overview of Zika virus genotypes and their infectivity
TypeArticle Review
Volume Number55
dc.accessType Open Access


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