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AuthorFairuz, Shadreen
AuthorNair, Rajesh Sreedharan
AuthorBilla, Nashiru
Available date2023-07-12T08:00:15Z
Publication Date2022-08-30
Publication NamePharmaceutics
Identifierhttp://dx.doi.org/10.3390/pharmaceutics14091823
CitationFairuz, S., Nair, R. S., & Billa, N. (2022). Orally Administered Amphotericin B Nanoformulations: Physical Properties of Nanoparticle Carriers on Bioavailability and Clinical Relevance. Pharmaceutics, 14(9), 1823.
ISSN1999-4923
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85138625379&origin=inward
URIhttp://hdl.handle.net/10576/45428
AbstractAmphotericin B is an effective polyene antifungal considered as a “gold standard” in the management of fungal infections. Currently, it is administered mainly by IV due to poor aqueous solubility, which precludes its delivery orally. Paradoxically, IV administration is akin to side effects that have not been fully eliminated even with more recent IV formulations. Thus, the need for alternative formulations/route of administration for amphotericin B remains crucial. The oral route offers the possibility of delivering amphotericin B systemically and with diminished side effects; however, enterocyte permeation remains a constraint. Cellular phagocytosis of submicron particles can be used to courier encapsulated drugs. In this regard, nanoparticulate delivery systems have received much attention in the past decade. This review examines the trajectory of orally delivered amphotericin B and discusses key physical factors of nanoformulations that impact bioavailability. The review also explores obstacles that remain and gives a window into the possibility of realizing an oral nanoformulation of amphotericin B in the near future.
SponsorThe research was funded by grant number Qatar University Grant: IRCC-2021-006.
Languageen
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
Subjectamphotericin B
bioavailability
clinical
nanoparticle
oral
TitleOrally Administered Amphotericin B Nanoformulations: Physical Properties of Nanoparticle Carriers on Bioavailability and Clinical Relevance
TypeArticle
Issue Number9
Volume Number14
ESSN1999-4923
dc.accessType Open Access


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