Browsing Biomedical Research Center Research by Author "Yalcin, Huseyin C."
Now showing items 41-57 of 57
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Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies.
Alser, Maha; Shurbaji, Samar; Yalcin, Huseyin C ( MDPI , 2021 , Article)The heart is the first organ that starts to function in a developing embryo. It continues to undergo dramatic morphological changes while pumping blood to the rest of the body. Genetic regulation of heart development is ... -
Minimally Invasive and Non-Invasive Technologies for Predicting Heart Failure
Salman, Huseyin Enes; Al-Ruweidi, Mahmoud Khatib A. A.; Quakad, Hassen M.; Yalcin, Huseyin C. ( Wiley , 2022 , Book chapter)Heart failure is a life-threatening medical problem which refers to inadequate blood supply to body tissues due to the limited functioning of heart muscles. Heart failure is mostly observed as a chronic disease which ... -
Nanotechnology in medicine – our experiences
Geskovski, Nikola; Mraiche, Fatima; Yalcin, Huseyin C.; Gorachinov, Filip; Moustafa, Diala A.; Dimchevska, Simona; Dodov, Marija Glavas; Crcarevska, Maja Simonoska; Goracinova, Katerina... more authors ... less authors ( Macedonian Pharmaceutical Association , 2022 , Article)The success of design criteria for long-circulating drug delivery systems to support membrane receptor-ligand interaction and internalization has been limited and there is a need to develop smarter approaches for efficient ... -
Nitric Oxide Releasing Hydrogel Nanoparticles Decreases Epithelial Cell Injuries Associated With Airway Reopening.
Shurbaji, Samar; El-Sherbiny, Ibrahim M; Alser, Maha; Ali, Isra H; Kordi, Haya; Al-Sadi, Ameena; Popelka, Anton; Benslimane, Fatiha; Yacoub, Magdi; Yalcin, Huseyin C... more authors ... less authors ( Frontiers , 2021 , Article)Acute respiratory distress syndrome (ARDS) is an acute inflammatory lung condition. It is characterized by disruption of gas exchange inside the alveoli, accumulation of protein edema, and an increase in lung stiffness. ... -
Preface
Yalcin, Huseyin C. ( Springer International Publishing , 2019 , Other)Since its foundation in 2018, Emergent Materials aimed to focus on evolving techniques/technologies for advanced materials in a wide variety of fields such as polymer science, composites, electronics, membranes, and ... -
Reduced Cardiotoxicity of Ponatinib-Loaded PLGA-PEG-PLGA Nanoparticles in Zebrafish Xenograft Model.
Al-Thani, Hissa F; Shurbaji, Samar; Zakaria, Zain Zaki; Hasan, Maram H; Goracinova, Katerina; Korashy, Hesham M; Yalcin, Huseyin C... more authors ... less authors ( MDPI , 2022 , Article)Tyrosine kinase inhibitors (TKIs) are the new generation of anti-cancer drugs with high potential against cancer cells' proliferation and growth. However, TKIs are associated with severe cardiotoxicity, limiting their ... -
The role of CD44, hyaluronan and NHE1 in cardiac remodeling.
Suleiman, Muna; Abdurrahman, Nabeel; yalcin, huseyin c; Mraiche, Fatima ( Elsevier , 2018 , Article)Cardiac remodeling, characterized by excessive extracellular matrix (ECM) remodeling, predisposes the heart to failure if left unresolved. Understanding the signaling mechanisms involved in excessive extracellular matrix ... -
The Role of p90 Ribosomal S6 Kinase (RSK) in Tyrosine Kinase Inhibitor (TKI)-Induced Cardiotoxicity
Suleiman, Muna; Al Najjar, Afnan; Zakaria, Zain Z.; Ahmed, Rashid; Yalcin, Huseyin C.; Korashy, Hesham M.; Uddin, Shahab; Riaz, Sadaf; Abdulrahman, Nabeel; Mraiche, Fatima... more authors ... less authors ( Springer , 2023 , Article Review)Targeted therapy, such as tyrosine kinase inhibitors (TKIs), has been approved to manage various cancer types. However, TKI-induced cardiotoxicity is a limiting factor for their use. This issue has raised the need for ... -
Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs.
A Elrayess, Mohamed; T Zedan, Hadeel; A Alattar, Rand; Abusriwil, Hatem; Al-Ruweidi, Mahmoud Khatib A A; Almuraikhy, Shamma; Parengal, Jabeed; Alhariri, Bassem; Yassine, Hadi M; A Hssain, Ali; Nair, Arun; Al Samawi, Musaed; Abdelmajid, Alaaeldin; Al Suwaidi, Jassim; Omar Saad, Mohamed; Al-Maslamani, Muna; Omrani, Ali S; Yalcin, Huseyin C... more authors ... less authors ( Taylor and Francis , 2022 , Article)This study examines the effect of antihypertensive drugs on ACE2 and Angiotensin II levels in hypertensive COVID-19 patients. Hypertension is a common comorbidity among severe COVID-19 patients. ACE2 expression can be ... -
Soluble ACE2 and Angiotensin II levels Modulated in Hypertensive COVID-19 Patients treated with different Antihypertension Drugs
Yalcin, Huseyin C.; Elrayess, Mohamed A; Al-Jighefee, Hadeel T; Al-Ruweidi, Mahmoud Khatib A. A.; Almuraikhy, Shamma; Yassine, Hadi M.... more authors ... less authors ( Qatar University Press , 2021 , Poster)Hypertension is a major risk factor and common comorbidity among severe Coronavirus Disease 2019 (COVID-19) patients. Prominent antihypertensive drugs, such as angiotensin-converting-enzyme inhibitors (ACEi) and angiotensin ... -
Substantial toxic effect of water-pipe smoking on the early stage of embryonic development
Ashour, Anas A; Haik, Mahmoud Y; Sadek, Khaled W; Yalcin, Huseyin C; Bitharas, Joanna; Aboulkassim, Tahar; Batist, Gerald; Yasmeen, Amber; Al Moustafa, Ala-Eddin... more authors ... less authors ( Oxford University Press , 2017 , Article)Water-pipe smoking (WPS) is the most widespread tobacco use in the Middle-East, and is rapidly spreading globally. Smoke from WP contains most of the compounds present in cigarette smoke, although in different proportions. ... -
Support of intelligent emergent materials to combat COVID-19 pandemic
Yalcin, Huseyin C.; Kaushik, Ajeet ( Springer , 2021 , Article)The COVID-19 pandemic, associated with SARS-CoV-2 infection transmitted via human to human and cause lifethreatening respiratory diseases, has emerged as an everincreasing global health and economic crisis since its ... -
Trilayer composite scaffold for urethral reconstruction: in vitro evaluation of mechanical, biological, and angiogenic properties
Abbas, Tariq O.; Parangusan, Hemalatha; Yalcin, Huseyin C.; Hassan, Mohamed; Zakrif, Lubna; Zandi, Nooshin; Pennisi, Cristian P.... more authors ... less authors ( IOP Publishing , 2024 , Article)Regeneration of damaged urethral tissue remains a major challenge in the field of lower urinary tract reconstruction. To address this issue, various synthetic and natural biodegradable biomaterials are currently being ... -
Understanding diabetes-induced cardiomyopathy from the perspective of renin angiotensin aldosterone system
Sukumaran, Vijayakumar; Gurusamy, Narasimman; Yalcin, Huseyin C; Venkatesh, Sundararajan ( Springer , 2021 , Article)Experimental and clinical evidence suggests that diabetic subjects are predisposed to a distinct cardiovascular dysfunction, known as diabetic cardiomyopathy (DCM), which could be an autonomous disease independent of ... -
Use of Animal Models for Investigating Cardioprotective Roles of SGLT2 Inhibitors
Al Thani, Najlaa A.; Hasan, Maram; Yalcin, Huseyin C. ( Springer , 2023 , Article Review)Sodium-glucose co-transporter 2 (SGLT2) inhibitors represent one type of new-generation type 2 diabetes (T2DM) drug treatment. The mechanism of action of an SGLT2 inhibitor (SGLT2i) in treating T2DM depends on lowering ... -
Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity
zakaria, zain z.; benslimane, fatiha m.; nasrallah, gheyath k.; shurbaji, samar; younes, nadin n.; Mraiche, Fatima; Da’as, Sahar I.; yalcin, huseyin c.... more authors ... less authors ( Hindawi Publishing Corporation , 2018 , Article)Over the last decade, the zebrafish (Danio rerio) has emerged as amodel organismfor cardiovascular research.Zebrafish have several advantages over mammalian models. For instance, the experimental cost of using zebrafish ... -
Zebrafish as a Model for Anticancer Nanomedicine Studies.
Al-Thani, Hissa F; Shurbaji, Samar; Yalcin, Huseyin C ( MDPI , 2021 , Article Review)Nanomedicine is a new approach to fight against cancer by the development of anticancer nanoparticles (NPs) that are of high sensitivity, specificity, and targeting ability to detect cancer cells, such as the ability of ...