Browsing Biomedical Research Center Research by Author "Abdelrahman, Doua"
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Deciphering metabolomics and lipidomics landscape in zebrafish hypertrophic cardiomyopathy model
Jacob, Shana; Abuarja, Tala; Shaath, Rulan; Hasan, Waseem; Balayya, Saroja; Abdelrahman, Doua; Almana, Khalid; Afreen, Hajira; Hani, Ahmad; Nomikos, Michail; Fakhro, Khalid; Elrayess, Mohamed A.; Da’as, Sahar Isa... more authors ... less authors ( Springer Nature , 2024 , Article)To elucidate the lipidomic and metabolomic alterations associated with hypertrophic cardiomyopathy (HCM) pathogenesis, we utilized cmybpc3-/- zebrafish model. Fatty acid profiling revealed variability of 10 fatty acids ... -
Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function
Da'as, Sahar I.; Thanassoulas, Angelos; Calver, Brian L.; Saleh, Alaaeldin; Abdelrahman, Doua; Hasan, Waseem; Safieh-Garabedian, Bared; Kontogianni, Iris; Nasrallah, Gheyath K.; Nounesis, George; Lai, F. Anthony; Nomikos, Michail... more authors ... less authors ( John Wiley & Sons , 2024 , Article)Calmodulin (CaM) is a ubiquitous, small cytosolic calcium (Ca2+)-binding sensor that plays a vital role in many cellular processes by binding and regulating the activity of over 300 protein targets. In cardiac muscle, CaM ... -
Prevalence and Phylogenetic Analysis of Parvovirus (B19V) among Blood Donors with Different Nationalities Residing in Qatar
Abdelrahman, Doua; Al-Sadeq, Duaa W.; Smatti, Maria K.; Taleb, Sara A.; AbuOdeh, Raed O.; Al-Absi, Enas S.; Al-Thani, Asmaa A.; Coyle, Peter. V.; Al-Dewik, Nader; Al Qahtani, Ahmed A.; Yassine, Hadi M.; Nasrallah, Gheyath K.... more authors ... less authors ( MDPI , 2021 , Article)Human parvovirus (B19V) is the causative agent of erythema infectiosum in children and is linked to a wide range of clinical manifestations. Studies related to B19V prevalence in the Middle East and North Africa (MENA) ... -
Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model
Da’as, Sahar Isa; Hasan, Waseem; Salem, Rola; Younes, Nadine; Abdelrahman, Doua; Mohamed, Iman A.; Aldaalis, Arwa; Temanni, Ramzi; Mathew, Lisa Sara; Lorenz, Stephan; Yacoub, Magdi; Nomikos, Michail; Nasrallah, Gheyath K.; Fakhro, Khalid A.... more authors ... less authors ( MDPI , 2022 , Article)Variants in cardiac myosin-binding protein C (cMyBP-C) are the leading cause of inherited hypertrophic cardiomyopathy (HCM), demonstrating the key role that cMyBP-C plays in the heart’s contractile machinery. To investigate ...