تصفح Biomedical Research Center Research حسب المؤلف "Giordo, Roberta"
-
Antioxidant Activity Mediates Pirfenidone Antifibrotic Effects in Human Pulmonary Vascular Smooth Muscle Cells Exposed to Sera of Idiopathic Pulmonary Fibrosis Patients.
Fois, Alessandro Giuseppe; Posadino, Anna Maria; Giordo, Roberta; Cossu, Annalisa; Agouni, Abdelali; Rizk, Nasser Moustafa; Pirina, Pietro; Carru, Ciriaco; Zinellu, Angelo; Pintus, Gianfranco... more authors ... less authors ( Hindawi Publishing Corporation , 2018 , Article)Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by an exacerbated fibrotic response. Although molecular and cellular determinants involved in the onset and progression of this devastating disease ... -
Cytoprotective, antioxidant, and anti-migratory activity of Pistacia lentiscus L. supercritical carbon dioxide extract on primary human endothelial cells
Giordo, Roberta; Cossu, Annalisa; Porcu, Maria Cristina; Cappuccinelli, Roberto; Biosa, Grazia; Sharifi-Rad, Javad; Pretti, Luca; Nasrallah, Gheyath K.; Pintus, Gianfranco; Posadino, Anna Maria... more authors ... less authors ( Taylor & Francis , 2022 , Article)Green chemistry is a useful tool for producing valuable chemicals from biomass. However, extracted compounds need to be tested for safety and efficacy before their use in humans. Here we investigate the chemical composition ... -
EndMT regulation by small RNAs in diabetes-associated fibrotic conditions: potential link with oxidative stress
Giordo, Roberta; Mohammed, Yusra; Allam, Hilda; Abusnana, Salah; Pappalardo, Lucia; Nasrallah, Gheyath; Mangoni, Arduino; Pintus, Gianfranco... more authors ... less authors ( Frontiers Media , 2021 , Article)Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ dysfunction, disability, and increased mortality. ... -
Flavin Oxidase-Induced ROS Generation Modulates PKC Biphasic Effect of Resveratrol on Endothelial Cell Survival.
Posadino, Anna Maria; Giordo, Roberta; Cossu, Annalisa; Nasrallah, Gheyath K; Shaito, Abdullah; Abou-Saleh, Haissam; Eid, Ali H; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2019 , Article)Dietary intake of natural antioxidants is thought to impart protection against oxidative-associated cardiovascular diseases. Despite many in vivo studies and clinical trials, this issue has not been conclusively resolved. ... -
Protective Effect of Cyclically Pressurized Solid⁻Liquid Extraction Polyphenols from Grape Pomace on Oxidative Endothelial Cell Death.
Posadino, Anna Maria; Biosa, Grazia; Zayed, Hatem; Abou-Saleh, Haissam; Cossu, Annalisa; Nasrallah, Gheyath K; Giordo, Roberta; Pagnozzi, Daniela; Porcu, Maria Cristina; Pretti, Luca; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2018 , Article)The aim of this work is the evaluation of a green extraction technology to exploit winery waste byproducts. Specifically, a solid⁻liquid extraction technology (Naviglio Extractor) was used to obtain polyphenolic antioxidants ... -
Reduced vasorin enhances angiotensin II signaling within the aging arterial wall
Pintus, Gianfranco; Giordo, Roberta; Yushi, Wang; Wanqu, Zhu; Soo, Hyuk Kim; Li, Zhang; Leng, Ni; Jing, Zhang; Richard, Telljohann; Kimberly, R. McGraw; Robert, E. Monticone; Chloe, Ferris; Lijuan, Liu; Mingyi, Wang; Edward, G. Lakatta... more authors ... less authors ( Impact Journals , 2018 , Article)The glycosylated protein vasorin physically interacts with the transforming growth factor-beta1 (TGF-β1) and functionally attenuates its fibrogenic signaling in the vascular smooth muscle cells (VSMCs) of the arterial wall. ... -
Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (Danio rerio)
Giordo, Roberta; Nasrallah, Gheyath; Al-Jamal, Ola; Paliogiannis, Panagiotis; Pintus, Gianfranco ( MDPI , 2020 , Article)Despite their wide industrial use, Zinc oxide (ZnO) nanoparticles (NPs) exhibit a high toxic potential while concerns of their health-related risks are still present, urging additional in vivo clarification studies. ... -
Resveratrol-mediated regulation of mitochondria biogenesis-associated pathways in neurodegenerative diseases: molecular insights and potential therapeutic applications.
Shaito, Abdullah; Al-Mansoob, Maryam; Ahmad, Salma M S; Haider, Mohammad Z; Eid, Ali H; Posadino, Anna Maria; Pintus, Gianfranco; Giordo, Roberta... more authors ... less authors ( Bentham Science Publisher , 2022 , Article Review)Neurodegenerative disorders include neurological conditions that affect nerve cells, causing the progressive loss of their functions and ultimately leading to loss of mobility, coordination, and mental functioning. The ...