Browsing Biomedical Research Center Research by Author "Khalil,Ashraf"
Now showing items 1-6 of 6
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A comprehensive review on the antiviral activities of chalcones
Elkhalifa, Dana; Al-Hashimi, Israa; Al Moustafa, Ala-Eddin; Khalil, Ashraf ( Taylor and Francis Ltd. , 2021 , Article)Some viral outbreaks have plagued the world since antiquity, including the most recent COVID-19 pandemic. The continuous spread and emergence of new viral diseases have urged the discovery of novel treatment options that ... -
A comprehensive review summarizing the recent biomedical applications of functionalized carbon nanofibers
Abdo, Ghada G.; Zagho, Moustafa M.; Al Moustafa, Ala-Eddin; Khalil, Ashraf; Elzatahry, Ahmed A. ( John Wiley and Sons Inc , 2021 , Article)Since the discovery and fabrication of carbon nanofibers (CNFs) over a decade ago, scientists foster to discover novel myriad potential applications for this material in both biomedicine and industry. The unique economic ... -
Development of Novel Chalcone Analogs as Potential Multi-Targeted Therapies for Castration-Resistant Prostate Cancer
Hussein, Ola; Alali, Feras; Al Mustafa, Ala?Eddin; Khalil, Ashraf ( Qatar University Press , 2021 , Poster)Prostate cancer (PCa) is the second most frequently diagnosed malignancy, as well as a leading cause of cancer-related mortality in men globally. Despite the initial response to hormonal targeted therapy, the majority of ... -
Novel polymethoxylated chalcones as potential compounds against kras-mutant colorectal cancers
Mahmoud, Alaa; Elkhalifa, Dana; Alali, Feras; Al Moustafa, Ala-Eddin; Khalil, Ashraf ( Bentham Science Publishers , 2020 , Article)Background/Objective: KRAS-mutant colorectal cancers (CRC) are tumors that are associated with poor prognosis. However, no effective treatments are available to target them. Therefore, we designed and synthesized novel ... -
Targeting triple negative breast cancer heterogeneity with chalcones: a molecular insight.
Elkhalifa, Dana; Alali, Feras; Al Moustafa, Ala-Eddin; Khalil, Ashraf ( Informa Healthcare , 2019 , Article Review)Triple negative breast cancers (TNBCs) are aggressive heterogeneous cancers with not yet determined conventional targeted medication. Therefore, identification of new alternatives or improved treatment options to combat ... -
Water-Pipe Smoking Exposure Deregulates a Set of Genes Associated with Human Head and Neck Cancer Development and Prognosis.
López-Ozuna, Vanessa M; Gupta, Ishita; Kiow, Ryan Liu Chen; Matanes, Emad; Kheraldine, Hadeel; Yasmeen, Amber; Khalil, Ashraf; Vranic, Semir; Al Moustafa, Ala-Eddin; Farsi, Halema F Al... more authors ... less authors ( MDPI , 2020 , Article)Water-pipe smoking (WPS) is becoming the most popular form of tobacco use among the youth, especially in the Middle East, replacing cigarettes rapidly and becoming a major risk of tobacco addiction worldwide. Smoke from ...