Biomedical Research Center Research: Recent submissions
Now showing items 621-640 of 734
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Performance of Four Diagnostic Assays for Detecting Herpes Simplex Virus Type 2 Antibodies in the Middle East and North Africa
( Elsevier , 2019 , Article)Background Assessments of commercial assays in detecting herpes simplex virus type 2 (HSV-2) antibodies have shown variable sensitivity and specificity, and variation in performance by global population. Objective To ... -
Evaluation of Antimicrobial Action of Chitosan and Acetic Acid on Broiler Cecal Bacterial Profiles in Anaerobic Cultures InoculatedWith Salmonella Typhimurium
( Oxford University Press , 2018 , Article)Chitosan is known to have antimicrobial properties against a range of microbes. In this study, three different molecular weight (MW) chitosan preparations were used: low (LMW), medium (MMW), and coarse (CMW), in acetic ... -
Characterization of Endothelial Cilia Distribution During Cerebral-Vascular Development in Zebrafish (Danio rerio)
( American Heart Association , 2018 , Article)Objective—Endothelial cells (ECs) sense and respond to flow-induced mechanical stress, in part, via microtubule-based projections called primary cilia. However, many critical steps during vascular morphogenesis occur ... -
Comparative Outer Membrane Protein Analysis of High and Low-Invasive Strains of Cronobacter malonaticus
( Frontiers Media , 2017 , Article)are an important group of foodborne pathogens that has been linked to life-threatening infections in both infants and adults. The major infections associated with species are neonatal meningitis, necrotizing enterocolitis, ... -
Antioxidant Activity Mediates Pirfenidone Antifibrotic Effects in Human Pulmonary Vascular Smooth Muscle Cells Exposed to Sera of Idiopathic Pulmonary Fibrosis Patients.
( Hindawi Publishing Corporation , 2018 , Article)Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by an exacerbated fibrotic response. Although molecular and cellular determinants involved in the onset and progression of this devastating disease ... -
Novel CD44-downstream signaling pathways mediating breast tumor invasion
( Ivyspring International Publisher , 2018 , Article Review)CD44, also known as homing cell adhesion molecule is a multi-structural cell molecule involved in cell-cell and cell-extracellular matrix communications. CD44 regulates a number of central signaling pathways, including ... -
Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity
( Hindawi Publishing Corporation , 2018 , Article)Over the last decade, the zebrafish (Danio rerio) has emerged as amodel organismfor cardiovascular research.Zebrafish have several advantages over mammalian models. For instance, the experimental cost of using zebrafish ... -
The Dual Specificity Role of Transcription Factor FOXO in Type 2-diabetes and Cancer
( Bentham Science Publishers , 2018 , Article Review)The FOXO (Forkhead box O) transcription factors are implicated in several signaling pathways and play a vital role in various cellular and physiological processes include for instance, ROS (reactive oxygen species) response, ... -
Computational screening of known broad-spectrum antiviral small organic molecules for potential influenza HA stem inhibitors.
( Public Library of Science , 2018 , Article)With the emergence of new influenza virus strains that are resistant to current inhibitors such as oseltamivir (anti-neuraminidase (NA)) and amantadine (anti-M2 proton channel), influenza A viruses continue to be a serious ... -
Generating an imagingbased approach for enhanced structural and functional analysis of zebrafish cardiovascular systems
( HBKU Press , 2018 , Conference Proceedings)Cardiovascular diseases (CVDs) have latterly become one of the leading cause of death and impairment worldwide. According to the World Health Organization (WHO), data estimation in 2008 were about 17.3, 7.3 and 6.2 million ... -
Protective Effect of Cyclically Pressurized Solid⁻Liquid Extraction Polyphenols from Grape Pomace on Oxidative Endothelial Cell Death.
( MDPI , 2018 , Article)The aim of this work is the evaluation of a green extraction technology to exploit winery waste byproducts. Specifically, a solid⁻liquid extraction technology (Naviglio Extractor) was used to obtain polyphenolic antioxidants ... -
Evolution and dynamics of the pandemic H1N1 influenza hemagglutinin protein from 2009 to 2017.
( Springer Vienna , 2018 , Article)The emergence of swine-origin pandemic H1N1 (pH1N1) in 2009 invigorated extensive surveillance programs worldwide which have resulted in the deposition of large numbers of H1N1 sequences to Genbank. In the present study, ... -
The role of CD44, hyaluronan and NHE1 in cardiac remodeling.
( Elsevier , 2018 , Article)Cardiac remodeling, characterized by excessive extracellular matrix (ECM) remodeling, predisposes the heart to failure if left unresolved. Understanding the signaling mechanisms involved in excessive extracellular matrix ... -
Hemodynamic Studies for Analyzing the Teratogenic Effects of Drugs in the Zebrafish Embryo.
( Humana Press , 2018 , Book chapter)Investigations of teratogenic effects of drugs generally involve testing the drug on animals and zebrafish embryo is a commonly used animal model for that purpose. In these studies, cardiovascular function of the animals ... -
Molecular characterization of extended spectrum β -lactamases enterobacteriaceae causing lower urinary tract infection among pediatric population.
( BioMed Central , 2018 , Article)The β-lactam antibiotics have traditionally been the main treatment of Enterobacteriaceae infections, nonetheless, the emergence of species producing β- Lactamases has rendered this class of antibiotics largely ineffective. ... -
VEGF-121 plasma level as biomarker for response to anti-angiogenetic therapy in recurrent glioblastoma.
( BioMed Central , 2018 , Article)Vascular endothelial growth factor (VEGF) isoforms, particularly the diffusible VEGF-121, could play a major role in the response of recurrent glioblastoma (GB) to anti-angiogenetic treatment with bevacizumab. We hypothesized ... -
Advances in osteobiologic materials for bone substitutes.
( John Wiley and Sons , 2018 , Article Review)A significant challenge in the current orthopedics is the development of suitable osteobiologic materials that can replace the conventional allografts, autografts, and xenografts and thereby serve as implant materials as ... -
Use of Hemagglutinin Stem Probes Demonstrate Prevalence of Broadly Reactive Group 1 Influenza Antibodies in Human Sera.
( Nature Publishing Group , 2018 , Article)A better understanding of the seroprevalence and specificity of influenza HA stem-directed broadly neutralizing antibodies (bNAbs) in the human population could significantly inform influenza vaccine design efforts. Here, ... -
Epstein–Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update
( Frontiers Medi , 2018 , Article Review)The Epstein–Barr virus (EBV) is a DNA lymphotropic herpesvirus and the causative agent of infectious mononucleosis. EBV is highly prevalent since it affects more than 90% of individuals worldwide and has been linked to ... -
Toxicity evaluation of selected ionic liquid compounds on embryonic development of Zebrafish.
( Elsevier , 2018 , Article)Hydrate formation in seafloor pipelines is considered an economic and flow assurance issue for the oil and gas industries. Ionic liquids (ILs) have been recently used as potential hydrate inhibitors. Although branded as ...
