Biomedical Research Center Research: Recent submissions

Now showing items 161-180 of 708

    • Cytoprotective, antioxidant, and anti-migratory activity of Pistacia lentiscus L. supercritical carbon dioxide extract on primary human endothelial cells 

      Giordo, Roberta; Cossu, Annalisa; Porcu, Maria Cristina; Cappuccinelli, Roberto; Biosa, Grazia; ... more authors ( Taylor & Francis , 2022 , Article)
      Green chemistry is a useful tool for producing valuable chemicals from biomass. However, extracted compounds need to be tested for safety and efficacy before their use in humans. Here we investigate the chemical composition ...

    • Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application 

      Marei, Hany E.; Althani, Asmaa; Afifi, Nahla; Hasan, Anwarul; Caceci, Thomas; ... more authors ( Springer , 2022 , Article Review)
      EV produced by tumour cells carry a diverse population of proteins, lipids, DNA, and RNA molecules throughout the body and appear to play an important role in the overall development of the disease state, according to ...

    • Long-term COVID-19 booster effectiveness by infection history and clinical vulnerability and immune imprinting: a retrospective population-based cohort study 

      Hiam, Chemaitelly; Ayoub, Houssein H; Tang, Patrick; Coyle, Peter; Yassine, Hadi M; ... more authors ( Elsevier , 2023 , Article)
      BackgroundLong-term effectiveness of COVID-19 mRNA boosters in populations with different previous infection histories and clinical vulnerability profiles is inadequately understood. We aimed to investigate the effectiveness ...

    • A new One Health Framework in Qatar for future emerging and re-emerging zoonotic diseases preparedness and response 

      Devendra, Bansal; Jaffrey, Shariq; Al-Emadi, Noora Abdulla; Hassan, Mahmoud; Islam, Md. Mazharul; ... more authors ( Elsevier , 2023 , Article)
      One Health is increasingly recognized as an optimal approach to address the global risk of health threats originating at the human, animal, and ecosystem interface, and their impact. Qatar has successfully practiced One ...

    • BNT162b2 antigen dose and SARS-CoV-2 omicron infection in adolescents 

      Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Yassine, Hadi M.; ... more authors ( Elsevier , 2023 , Other)
      COVID-19 vaccine antigen dose might affect protection against SARS-CoV-2 infection,1, 2 but direct evidence to quantify this effect is absent. We conducted a matched, retrospective, cohort study using a regression ...

    • Screening and diagnostic testing protocols for HIV and Syphilis infections in health care setting in Qatar: Evaluation and recommendations 

      Nasrallah, Gheyath K.; Al-Buainain, Raniya; Younes, Nadin; Dargham, Soha R.; Al-Sadeq, Duaa W.; ... more authors ( Public Library of Science , 2023 , Article)
      Background HIV and Syphilis are common STIs, which have become a concern and burden on healthcare systems, as many infections go untreated and lead to potentially serious complications. HIV is usually diagnosed with Western ...

    • Persistence of spike-specific immune responses in BNT162b2-vaccinated donors and generation of rapid ex-vivo T cells expansion protocol for adoptive immunotherapy: A pilot study 

      Mestiri, Sarra; Merhi, Maysaloun; Inchakalody, Varghese P.; Taib, Nassiba; Smatti, Maria K.; ... more authors ( Frontiers Media , 2023 , Article)
      Introduction: The BNT162b2 mRNA-based vaccine has shown high efficacy in preventing COVID-19 infection but there are limited data on the types and persistence of the humoral and T cell responses to such a vaccine. Methods: ...

    • Vaccine evaluation and genotype characterization in children infected with rotavirus in Qatar 

      Mathew, Shilu; Al Khatib, Hebah A.; Al Ibrahim, Malak; Al Ansari, Khalid; Smatti, Maria K.; ... more authors ( Springer Nature , 2023 , Article)
      Background: We characterized and identified the genetic and antigenic variations of circulating rotavirus strains in comparison to used rotavirus vaccines. Methods: Rotavirus-positive samples (n = 231) were collected and ...

    • Protection against Reinfection with the Omicron BA.2.75 Subvariant 

      Chemaitelly, Hiam; Tang, Patrick; Coyle, Peter; Yassine, Hadi M.; Al-Khatib, Hebah A.; ... more authors ( Massachusetts Medical Society , 2023 , Other)
      The BA.2.75 sublineage of the B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may escape neutralizing antibodies. The BA.2.75 sublineage (primarily the BA.2.75.2 subvariant) ...

    • Epac as a tractable therapeutic target 

      Hasan, Slika; Mansour, Hadi; Nasser, Suzanne A.; Shaito, Abdullah; Kobeissy, Firas; ... more authors ( Elsevier , 2023 , Article)
      In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing ...

    • Pandemic COVID-19 caused by SARS-CoV-2: genetic structure, vaccination, and therapeutic approaches 

      Marei, Hany E.; Althani, Asmaa; Afifi, Nahla; Pozzoli, Giacomo; Caceci, Thomas; ... more authors ( Springer , 2021 , Article Review)
      We give a summary of SARS-genetic CoV-2’s structure and evolution, as well as current attempts to develop efficient vaccine and treatment methods for SARS-CoV-2 infection, in this article. Most therapeutic strategies are ...

    • Qatar genome: Insights on genomics from the Middle East 

      Mbarek, Hamdi; Devadoss Gandhi, Geethanjali; Selvaraj, Senthil; Al-Muftah, Wadha; Badji, Radja; ... more authors ( Wiley , 2022 , Article)
      Despite recent biomedical breakthroughs and large genomic studies growing momentum, the Middle Eastern population, home to over 400 million people, is underrepresented in the human genome variation databases. Here we ...

    • Ultrasound controlled paclitaxel releasing system—A novel method for improving the availability of coronary artery drug coated balloon 

      Song, Caixia; Zhou, Chao; Zhang, Junwei; Feng, Xiangyi; Cui, Xiaoshan; ... more authors ( Wiley , 2020 , Article)
      Objectives: The aim of this study is to improve local-drug delivery efficiency and tissue absorption using the ultrasound (US)-responsible drug coating based on a newly developed US-controlled paclitaxel release balloon. ...

    • Nanomedicine as a Potential Tool against Monkeypox. 

      Mohamed, Nura Adam; Zupin, Luisa; Mazi, Sarah Ismail; Al-Khatib, Hebah A; Crovella, Sergio ( MDPI , 2023 , Article Review)
      Human monkeypox is a rare viral zoonosis that was first identified in 1970; since then, this infectious disease has been marked as endemic in central and western Africa. The disease has always been considered rare and ...

    • Traumatic Brain Injury Can Affect Emotions and Behaviors 

      Shakkour, Zaynab; Habashy, Karl John; Haidar, Muhammad Ali; Nasrallah, Leila; Tabet, Maha; ... more authors ( Frontiers Media , 2023 , Article)
      Proper brain functioning is responsible for our feelings, behavior, and thinking. However, an injury to the brain can disrupt brain function, which can affect our emotions and behaviors. A traumatic brain injury (TBI) can ...

    • Nox2 activity is required in obesity-mediated alteration of bone remodeling 

      Rahman, Md Mizanur; El Jamali, Amina; Halade, Ganesh V.; Ouhtit, Allal; Abou-Saleh, Haissam; ... more authors ( Hindawi Limited , 2018 , Article)
      Despite increasing evidence suggesting a role for NADPH oxidases (Nox) in bone pathophysiology, whether Nox enzymes contribute to obesity-mediated bone remodeling remains to be clearly elucidated. Nox2 is one of the ...

    • The power of phytochemicals combination in cancer chemoprevention 

      Rizeq, Balsam; Gupta, Ishita; Ilesanmi, Josephine; AlSafran, Mohammed; Rahman, MD Mizanur; ... more authors ( Ivyspring International Publisher , 2020 , Article Review)
      Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have ...

    • Antibody-Dependent Enhancement (ADE) and the role of complement system in disease pathogenesis 

      Thomas, Swapna; Smatti, Maria K.; Ouhtit, Allal; Cyprian, Farhan S.; Almaslamani, Muna A.; ... more authors ( Elsevier Ltd , 2022 , Article Review)
      Antibody-dependent enhancement (ADE) has been associated with severe disease outcomes in several viral infections, including respiratory infections. In vitro and in vivo studies showed that antibody-response to SARS-CoV ...

    • Intercellular Communication in Cancer 

      Shaito, Abdullah; Saliba, Jessica; Obeid, Joelle; El-Harakeh, Mohammad; El Hajj, Hiba; ... more authors ( Springer , 2023 , Book chapter)
      Junctional complexes play a central role in maintaining tissue hemostasis. The barrier function of epithelial cells, that maintain tissues coherence and coordination of cellular synchronicity, is a consequence of a junctional ...

    • Ubiquitin-Related Modifier 1 (URM-1) Modulates Cx43 in Breast Cancer Cell Lines. 

      El-Hajjar, Layal; Saliba, Jessica; Karam, Mario; Shaito, Abdullah; El Hajj, Hiba; ... more authors ( MDPI , 2023 , Article)
      Gap-junction-forming connexins are exquisitely regulated by post-translational modifications (PTMs). In particular, the PTM of connexin 43 (Cx43), a tumor suppressor protein, regulates its turnover and activity. Here, we ...