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AuthorAmekyeh, Hilda
AuthorBilla, Nashiru
Available date2023-07-31T09:25:04Z
Publication Date2021-02-02
Publication NameMolecules
Identifierhttp://dx.doi.org/10.3390/molecules26040908
CitationAmekyeh, H., & Billa, N. (2021). Lyophilized drug-loaded solid lipid nanoparticles formulated with beeswax and theobroma oil. Molecules, 26(4), 908.‏
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85101467061&origin=inward
URIhttp://hdl.handle.net/10576/46430
AbstractSolid lipid nanoparticles (SLNs) have the potential to enhance the systemic availability of an active pharmaceutical ingredient (API) or reduce its toxicity through uptake of the SLNs from the gastrointestinal tract or controlled release of the API, respectively. In both aspects, the responses of the lipid matrix to external challenges is crucial. Here, we evaluate the effects of lyophilization on key responses of 1:1 beeswax–theobroma oil matrix SLNs using three model drugs: Amphotericin B (AMB), paracetamol (PAR), and sulfasalazine (SSZ). Fresh SLNs were stable with sizes ranging between 206.5–236.9 nm. Lyophilization and storage for 24 months (4–8 °C) caused a 1.6- and 1.5-fold increase in size, respectively, in all three SLNs. Zeta potential was >60 mV in fresh, stored, and lyophilized SLNs, indicating good colloidal stability. Drug release was not significantly affected by lyophilization up to 8 h. Drug release percentages at end time were 11.8 ± 0.4, 65.9 ± 0.04, and 31.4 ± 1.95% from fresh AMB-SLNs, PAR-SLNs, and SSZ-SLNs, respectively, and 11.4 ± 0.4, 76.04 ± 0.21, and 31.6 ± 0.33% from lyophilized SLNs, respectively. Thus, rate of release is dependent on API solubility (AMB < SSZ < PAR). Drug release from each matrix followed the Higuchi model and was not affected by lyophilization. The above SLNs show potential for use in delivering hydrophilic and lipophilic drugs.
Languageen
PublisherMDPI AG
SubjectBeeswax
Drug release
Lyophilisation
Solid lipid nanoparticle
Theobroma oil
TitleLyophilized drug-loaded solid lipid nanoparticles formulated with beeswax and theobroma oil
TypeArticle
Issue Number4
Volume Number26


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