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المؤلفFardoun, Manal Muin
المؤلفMaaliki, Dina
المؤلفHalabi, Nabil
المؤلفIratni, Rabah
المؤلفBitto, Alessandra
المؤلفBaydoun, Elias
المؤلفEid, Ali H.
تاريخ الإتاحة2023-08-29T10:21:48Z
تاريخ النشر2020
اسم المنشورClinical Science
المصدرScopus
الرقم المعياري الدولي للكتاب1435221
معرّف المصادر الموحدhttp://dx.doi.org/10.1042/CS20200356
معرّف المصادر الموحدhttp://hdl.handle.net/10576/46996
الملخصFlavonoids are polyphenolic compounds naturally occurring in fruits and vegetables, in addition to beverages such as tea and coffee. Flavonoids are emerging as potent therapeutic agents for cardiovascular as well as metabolic diseases. Several studies corroborated an inverse relationship between flavonoid consumption and cardiovascular disease (CVD) or adipose tissue inflammation (ATI). Flavonoids exert their anti-atherogenic effects by increasing nitric oxide (NO), reducing reactive oxygen species (ROS), and decreasing pro-inflammatory cytokines. In addition, flavonoids alleviate ATI by decreasing triglyceride and cholesterol levels, as well as by attenuating inflammatory mediators. Furthermore, flavonoids inhibit synthesis of fatty acids and promote their oxidation. In this review, we discuss the effect of the main classes of flavonoids, namely flavones, flavonols, flavanols, flavanones, anthocyanins, and isoflavones, on atherosclerosis and ATI. In addition, we dissect the underlying molecular and cellular mechanisms of action for these flavonoids. We conclude by supporting the potential benefit for flavonoids in the management or treatment of CVD; yet, we call for more robust clinical studies for safety and pharmacokinetic values.
راعي المشروعThis publication was made possible by an MPP fund [grant number 320133] and a Farouk Jabre Award from the American University of Beirut (to Ali H. Eid).
اللغةen
الناشرPortland Press Ltd
الموضوعadipose tissue inflammation
atherosclerosis
cardiovascular disease
flavonoids
obesity
العنوانFlavonoids in adipose tissue inflammation and atherosclerosis: One arrow, two targets
النوعArticle Review
الصفحات1403-1432
رقم العدد12
رقم المجلد134
dc.accessType Abstract Only


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