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AuthorFardoun, Manal Muin
AuthorMaaliki, Dina
AuthorHalabi, Nabil
AuthorIratni, Rabah
AuthorBitto, Alessandra
AuthorBaydoun, Elias
AuthorEid, Ali H.
Available date2023-08-29T10:21:48Z
Publication Date2020
Publication NameClinical Science
ResourceScopus
ISSN1435221
URIhttp://dx.doi.org/10.1042/CS20200356
URIhttp://hdl.handle.net/10576/46996
AbstractFlavonoids are polyphenolic compounds naturally occurring in fruits and vegetables, in addition to beverages such as tea and coffee. Flavonoids are emerging as potent therapeutic agents for cardiovascular as well as metabolic diseases. Several studies corroborated an inverse relationship between flavonoid consumption and cardiovascular disease (CVD) or adipose tissue inflammation (ATI). Flavonoids exert their anti-atherogenic effects by increasing nitric oxide (NO), reducing reactive oxygen species (ROS), and decreasing pro-inflammatory cytokines. In addition, flavonoids alleviate ATI by decreasing triglyceride and cholesterol levels, as well as by attenuating inflammatory mediators. Furthermore, flavonoids inhibit synthesis of fatty acids and promote their oxidation. In this review, we discuss the effect of the main classes of flavonoids, namely flavones, flavonols, flavanols, flavanones, anthocyanins, and isoflavones, on atherosclerosis and ATI. In addition, we dissect the underlying molecular and cellular mechanisms of action for these flavonoids. We conclude by supporting the potential benefit for flavonoids in the management or treatment of CVD; yet, we call for more robust clinical studies for safety and pharmacokinetic values.
SponsorThis publication was made possible by an MPP fund [grant number 320133] and a Farouk Jabre Award from the American University of Beirut (to Ali H. Eid).
Languageen
PublisherPortland Press Ltd
Subjectadipose tissue inflammation
atherosclerosis
cardiovascular disease
flavonoids
obesity
TitleFlavonoids in adipose tissue inflammation and atherosclerosis: One arrow, two targets
TypeArticle Review
Pagination1403-1432
Issue Number12
Volume Number134
dc.accessType Abstract Only


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