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AuthorAhmed, Ali
AuthorTanveer, Maria
AuthorDujaili, Juman Abdulelah
AuthorChuah, Lay Hong
AuthorHashmi, Furqan Khurshid
AuthorAwaisu, Ahmed
Available date2023-09-03T06:44:17Z
Publication Date2023
Publication NameAIDS Patient Care and STDs
ResourceScopus
ISSN10872914
URIhttp://dx.doi.org/10.1089/apc.2022.0192
URIhttp://hdl.handle.net/10576/47154
AbstractPeople living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS; PLWHA) frequently encounter antiretroviral (ARV) therapy-related problems. Clinical pharmacists with specialized training in ARV stewardship play an important role in managing these problems. However, there is a paucity of evidence to clarify the impact of clinical pharmacists' interventions on managing ARV therapy-related problems in PLWHA. Therefore, we aim to systematically review the literature to determine the nature and impact of pharmacists' interventions on managing medication-related problems in PLWHA. The review protocol was registered on International Prospective Register of Systematic Reviews (PROSPERO; CRD42020173078). Relevant records were identified from six electronic bibliographic databases (PubMed, Embase, EBSCOhost, ProQuest, Scopus, and the Cochrane Central Register) from their inception until September 2022. We included all randomized and nonrandomized interventional studies that were published in English. After the abstract and full-text screening, data were extracted from the selected studies, and the quality of the studies was assessed. The electronic database search and citation tracking identified two thousand and three citations. The review included 21 of these studies, involving 2998 PLWHA, published between 2014 and 2022. Pharmacists' interventions, working alone or in a multi-disciplinary team, comprised ARV medication review, management of adverse drug reactions (ADRs), therapeutic drug monitoring, prevention of drug interactions, and provision of drug information to PLWHA or the health care team. The pharmacist-involved interventions significantly reduced incorrect/incomplete ARV regimens, drug interactions, incorrect dosages, duplicate therapy, polypharmacy, administration errors, missing medication, wrong formulation, ADRs, and prescribing errors. Most studies reported that physicians usually accept more than 90% of the pharmacists' recommendations. ARV medication-related problems remain highly prevalent in PLWHA. Pharmacist-led interventions and stewardship significantly reduce ARV therapy-related problems in PLWHA and are widely accepted by physicians. Dedicated pharmacists with specialized training and credentialing in infectious diseases or HIV/AIDS have a great potential to improve health outcomes in PLWHA.
Languageen
PublisherMary Ann Liebert Inc.
SubjectART
human immunodeficiency virus
medication errors
medication-related problems
pharmaceutical care
pharmacist
TitlePharmacist-Involved Antiretroviral Stewardship Programs in People Living with HIV/AIDS: A Systematic Review
TypeArticle Review
Pagination31-52
Issue Number1
Volume Number37
dc.accessType Abstract Only


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