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المؤلفFardoun, Manal
المؤلفAl-Shehabi, Tuqa
المؤلفEl-Yazbi, Ahmed
المؤلفIssa, Khodr
المؤلفZouein, Fouad
المؤلفMaaliki, Dina
المؤلفIratni, Rabah
المؤلفEid, Ali H.
تاريخ الإتاحة2023-09-06T05:27:58Z
تاريخ النشر2017
اسم المنشورOxidative Medicine and Cellular Longevity
المصدرScopus
الرقم المعياري الدولي للكتاب19420900
معرّف المصادر الموحدhttp://dx.doi.org/10.1155/2017/4134093
معرّف المصادر الموحدhttp://hdl.handle.net/10576/47271
الملخصCardiovascular disease (CVD) continues to be the leading cause of death worldwide. Atherosclerosis is a CVD characterized by plaque formation resulting from inflammation-induced insults to endothelial cells, monocytes, and vascular smooth muscle cells (VSMCs). Despite significant advances, current treatments for atherosclerosis remain insufficient, prompting the search for alternative modalities, including herbal medicine. Ziziphus nummularia is an herb commonly used in the amelioration of symptoms associated with many health conditions such as cold, diarrhea, cancer, and diabetes. However, its effect on the inflammation-induced behavior of VSMCs remains unknown. In this study, we sought to determine the effect of the ethanolic extract of Z. nummularia (ZNE) on TNF-α-induced phenotypic changes of human aortic smooth muscle cells (HASMCs). The treatment of HASMCs with ZNE decreased cell proliferation, adhesion to fibronectin, migration, and invasion. ZNE treatment also caused a concentration- and time-dependent reduction in the TNF-α-induced expression of matrix metalloproteases MMP-2 and MMP-9, NF-κB, and cell adhesion molecules ICAM-1 and VCAM-1. Furthermore, ZNE decreased the adhesion of THP-1 monocytes to HASMCs and endothelial cells in a concentration-dependent manner. These data provide evidence for the anti-inflammatory effect of Ziziphus nummularia, along with potential implications for its use as an agent that could ameliorate inflammation-induced atherogenic phenotype of VSMCs in atherosclerosis.
اللغةen
الناشرHindawi Limited
الموضوعAorta
Atherosclerosis
Cell Proliferation
Cells, Cultured
Gene Expression Regulation
Humans
Inflammation
Muscle Proteins
Myocytes, Smooth Muscle
Plant Extracts
Ziziphus
العنوانZiziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells
النوعArticle
رقم المجلد2017
dc.accessType Open Access


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