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AuthorFardoun, Manal
AuthorAl-Shehabi, Tuqa
AuthorEl-Yazbi, Ahmed
AuthorIssa, Khodr
AuthorZouein, Fouad
AuthorMaaliki, Dina
AuthorIratni, Rabah
AuthorEid, Ali H.
Available date2023-09-06T05:27:58Z
Publication Date2017
Publication NameOxidative Medicine and Cellular Longevity
ResourceScopus
ISSN19420900
URIhttp://dx.doi.org/10.1155/2017/4134093
URIhttp://hdl.handle.net/10576/47271
AbstractCardiovascular disease (CVD) continues to be the leading cause of death worldwide. Atherosclerosis is a CVD characterized by plaque formation resulting from inflammation-induced insults to endothelial cells, monocytes, and vascular smooth muscle cells (VSMCs). Despite significant advances, current treatments for atherosclerosis remain insufficient, prompting the search for alternative modalities, including herbal medicine. Ziziphus nummularia is an herb commonly used in the amelioration of symptoms associated with many health conditions such as cold, diarrhea, cancer, and diabetes. However, its effect on the inflammation-induced behavior of VSMCs remains unknown. In this study, we sought to determine the effect of the ethanolic extract of Z. nummularia (ZNE) on TNF-α-induced phenotypic changes of human aortic smooth muscle cells (HASMCs). The treatment of HASMCs with ZNE decreased cell proliferation, adhesion to fibronectin, migration, and invasion. ZNE treatment also caused a concentration- and time-dependent reduction in the TNF-α-induced expression of matrix metalloproteases MMP-2 and MMP-9, NF-κB, and cell adhesion molecules ICAM-1 and VCAM-1. Furthermore, ZNE decreased the adhesion of THP-1 monocytes to HASMCs and endothelial cells in a concentration-dependent manner. These data provide evidence for the anti-inflammatory effect of Ziziphus nummularia, along with potential implications for its use as an agent that could ameliorate inflammation-induced atherogenic phenotype of VSMCs in atherosclerosis.
Languageen
PublisherHindawi Limited
SubjectAorta
Atherosclerosis
Cell Proliferation
Cells, Cultured
Gene Expression Regulation
Humans
Inflammation
Muscle Proteins
Myocytes, Smooth Muscle
Plant Extracts
Ziziphus
TitleZiziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells
TypeArticle
Volume Number2017
dc.accessType Open Access


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