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AuthorAl-Ansari, Dana E.
AuthorMohamed, Nura A.
AuthorMarei, Isra
AuthorZekri, Atef
AuthorKameno, Yu
AuthorDavies, Robert P.
AuthorLickiss, Paul D.
AuthorRahman, Md Mizanur
AuthorAbou-Saleh, Haissam
Available date2023-09-06T09:36:57Z
Publication Date2020-05-27
Publication NameNanomaterials
Identifierhttp://dx.doi.org/10.3390/nano10061028
CitationAl-Ansari, D. E., Mohamed, N. A., Marei, I., Zekri, A., Kameno, Y., Davies, R. P., ... & Abou-Saleh, H. (2020). Internalization of metal–organic framework nanoparticles in human vascular cells: implications for cardiovascular disease therapy. Nanomaterials, 10(6), 1028.
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85086360118&origin=inward
URIhttp://hdl.handle.net/10576/47305
AbstractCardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Alteration of endothelial cells and the underlying vasculature plays a central role in the pathogenesis of various CVDs. The application of nanoscale materials such as nanoparticles in biomedicine has opened new horizons in the treatment of CVDs. We have previously shown that the iron metal-organic framework nanoparticle, Materials Institut Lavoisier-89 (nanoMIL-89) represents a viable vehicle for future drug delivery of pulmonary arterial hypertension. In this study, we have assessed the cellular uptake of nanoMIL-89 in pulmonary artery endothelial and smooth muscle cells using microscopy imaging techniques. We also tested the cellular responses to nanoMIL-89 using molecular and cellular assays. Microscopic images showed cellular internalization of nanoMIL-89, packaging into endocytic vesicles, and passing to daughter cells during mitosis. Moreover, nanoMIL-89 showed anti-inflammatory activity without any significant cytotoxicity. Our results indicate that nanoMIL-89 formulation may offer promising therapeutic opportunities and set forth a new prototype for drug delivery not only in CVDs, but also for other diseases yet incurable, such as diabetes and cancer.
Sponsor- The UREP grant [22-140-3-023] from Qatar National Research Fund (QNRF), a member of Qatar Foundation. - The Pickford Award from the British Pharmacological Society (awarded to NAM). - PDRA grants [PDRA3-0324-17001 and PDRA4-0129-18003] from QNRF.
Languageen
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
SubjectCardiovascular diseases
Endothelial cells
Metal-organic framework nanoparticles
MIL- 89
Nanomedicine
Smooth muscle cells
TitleInternalization of metal-organic framework nanoparticles in human vascular cells: Implications for cardiovascular disease therapy
TypeArticle
Issue Number6
Volume Number10
ESSN2079-4991
dc.accessType Open Access


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