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المؤلفAbuOdeh, Raed
المؤلفAl-Mawlawi, Naema
المؤلفAl-Qahtani, Ahmed
المؤلفBohol, Marie Fe F.
المؤلفAl-Ahdal, Mohammed N.
المؤلفHasan, Haydar A.
المؤلفAbuOdeh, Lamees
المؤلفNasrallah, Gheyath K.
تاريخ الإتاحة2016-09-22T07:03:44Z
تاريخ النشر2015-02
اسم المنشورJournal of Medical Virology
المعرّفhttp://dx.doi.org/10.1002/jmv.24146
الاقتباسAbuOdeh, R., Al-Mawlawi, N., Al-Qahtani, A. A., Bohol, M. F. F., Al-Ahdal, M. N., Hasan, H. A., AbuOdeh, L. and Nasrallah, G. K. (2015), "Detection and genotyping of torque teno virus (TTV) in healthy blood donors and patients infected with HBV or HCV in Qatar." Journal of Med. Virol., 87: 1184–1191.
الرقم المعياري الدولي للكتاب0146-6615
معرّف المصادر الموحدhttp://hdl.handle.net/10576/4758
الملخصTorque Teno virus (TTV) has been associated with non A–G hepatitis. The goal of this study was to estimate the infection rates and genotypic characteristics of TTV in the State of Qatar. A total of 644 blood samples representing different nationalities: (i) Qatari (118) and (ii) non- Qatari (526) nationals (mostly from Arab and South Eeast Asia countries) were tested for the presence of TTV DNA by nested PCR. The majority (573) of the blood samples belonged to healthy blood donors, whereas 54 and 53 of the blood samples belonged to patients infected with hepatitis B virus (HBV) and hepatitis C virus (HCV), respectively. The results obtained showed that the TTV infection rates in the healthy blood donors, and those infected with HBV or HCV patients were 81.4, 90.75 and 84.9%, respectively. Significant association between TTV viremia and age, or nationality was observed. Sequence analysis of PCR fragments amplified from the 50-untranslated region (50- UTR) of all (531) TTV positive samples showed that 65.5% (348/531) of the PCR fragment sequences were classified into main genogroup 3, followed by main genogroups 5 (24%), 2 (5.8%), and 1 (4.7%). Genogroup 4 was not detected among the our studied subjects. Phylogenetic and pairwise analyses using sequences from TTV viremic samples also showed an overall close similarity to the main genogroup 3. In conclusion, there was no significant difference in the rates of TTV detection among Qataris and non-Qataris and several genotypes, mainly genotype 3, were isolated.
راعي المشروعQatar National Research Fund (Qatar Foundation) Grant number: UREP 15-015-3-006.
اللغةen
الناشرWiley Periodicals, Inc
الموضوعphylogenetic analysis
HBV
HCV
TTV
PCR
العنوانDetection and Genotyping of Torque Teno Virus (TTV) in Healthy Blood Donors and Patients Infected With HBV or HCV in Qatar
النوعArticle
الصفحات1184-1191
رقم العدد7
رقم المجلد87
dc.accessType Abstract Only


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