Evaluation of the Validity of SAMe-TT2R2 Score in a Cohort of Venous Thromboembolism Patients Treated With Warfarin
Author | Alhmoud, Eman Nawash |
Author | Elewa, Hazem |
Author | Abdul Gelil, Mohammed S. |
Author | Abd El Samad, Osama B. |
Author | Elzouki, Abdelnasser Y. |
Available date | 2023-09-20T08:47:11Z |
Publication Date | 2020 |
Publication Name | Clinical and Applied Thrombosis/Hemostasis |
Resource | Scopus |
ISSN | 10760296 |
Abstract | Low SAMe-TT2R2 score of <2 was validated as a predictor of optimum anticoagulation control, reflected by mean time in therapeutic range (TTR) above 65% to 70%, among warfarin-treated atrial fibrillation patients. This study aimed to validate the ability of SAMe-TT2R2 score and its individual components in predicting anticoagulation control (mean TTR and clinical events) among a cohort of venous thromboembolism (VTE) patients in Qatar. A total of 295 patients were retrospectively evaluated. There was a trend toward statistical significance in mean TTR between low (<2) and high (≥ 2) SAMe-TT2R2 score groups (P = .05), a difference that was not sustained when a cutoff of 3 was used (ie, a score of 3 or more). Patients with poor INR control (TTR <70%) were numerically less likely to have SAMe-TT2R2 score of <2 compared with those with good INR control, though the difference was not statistically significant (16.7% vs 83.3%, respectively, P = .4). No thromboembolic events were reported, and no association was found between the score and risk of bleeding. Non-Caucasian origin was the only significant predictor of good anticoagulation in the studied cohort. In conclusion, SAMe-TT2R2 score could not predict quality of anticoagulation control in a cohort of VTE patients treated with warfarin in Qatar. Contribution of other clinical factors and whether a different scoring may yield better prediction of anticoagulation control remains to be tested. |
Sponsor | The authors disclose receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Medical Research Center in Hamad Medical Corporation. The authors would like to thank Mr Walid Mekkawi and Dr Sayed Yameen, senior pharmacists, for their contribution in data collection. The authors disclose receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Medical Research Center in Hamad Medical Corporation. |
Language | en |
Publisher | SAGE Publications Inc. |
Subject | anticoagulation control SAMe-TT2R2 score time in therapeutic range venous thromboembolism |
Type | Article |
Volume Number | 26 |
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